| 奈非西坦的合成研究 |
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| 引用本文： | 刘西梅,凌云,熊远珍,涂国刚,冯丽华.奈非西坦的合成研究[J].江西化工,2010(2):5-9. |
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| 作者姓名： | 刘西梅 凌云 熊远珍 涂国刚 冯丽华 |
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| 作者单位： | 南昌大学药学院,南昌,330006 |
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| 摘 要： | 奈非西坦是新研制的一种对阿尔茨海默氏病和脑血管后遗症有良好的临床治疗价值的药物。对奈非西坦的各种合成方法进行了总结,分析了各路线的优缺点,并对奈非西坦的药理学内容做了概述。
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| 关 键 词： | g-氨基丁酸 合成 2-氯-N-（2 6-二甲基苯基）乙酰胺 2-吡咯烷酮 |
A Review on the Research of Nefiracetam |
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| LIU Xi-mei,LING Yun,Xiong Yuan-zhen,Tu Guo-qiang,FENG Li-hua.A Review on the Research of Nefiracetam[J].Jiangxi Chemical Industry,2010(2):5-9. |
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| Authors: | LIU Xi-mei LING Yun Xiong Yuan-zhen Tu Guo-qiang FENG Li-hua |
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| Affiliation: | LIUXi-mei LINGYun XiongYuan-zhen TuGuo-qiang FENGLi-hua ( Pharmacy department of Nan Chang University, Nanchang 330006) |
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| Abstract: | N - （ 2,6 - Dimethylphenyl ） - 2 - oxo - 1 - pyrrolidineaeetamide, which is also called Nefiracetam, now has been proved to be an newly effective clinical drug for the therapies of Alzheimer disease and cerebrovascular sequelae. However, the review on the medicine at home and abroad is far away from maturity. Therefore, it is quite necessary to car- ry out a summary on the research of Nefiracetam. In this article, a review aiming at providing fundamental scientific basis for its further research is developed, mainly concerning on synthetic methods and comparison, pharmacology, and so on. |
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| Keywords: | γ - aminobutyric acid 2 - chloro - N - （2 6 - dimethylphenyl） acetamide 2 - pyrrolidone synthesis |
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