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Resolution by Preferential Crystallization of Proxyphylline by Using Its Salicylic Acid Monohydrate Co-Crystal |
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| Authors: | Lina C Harfouche Clément Brandel Yohann Cartigny Samuel Petit Gérard Coquerel |
| Affiliation: | 1. University of Rouen, SMS, Normandie University, 76000 Rouen, France;2. University of Rouen, SMS, Normandie University, 76000 Rouen, France
All authors contributed equally to this article.;3. University of Rouen, SMS, Normandie University, 76000 Rouen, France National Central University, Department of Chemical and Materials Engineering, 300 Zhongda Road, Zhongli District, 32001 Taoyuan City, Taiwan All authors contributed equally to this article. |
| Abstract: | The monohydrated co-crystal composed of the chiral active pharmaceutical ingredient proxyphylline, salicylic acid, and water was successfully resolved by preferential crystallization from a water/ethanol mixture. To the best of our knowledge, this is the first report of preferential crystallization applied to such a system and the results reveal that unusually high enantiomeric excess values can be attained in the mother liquor. These robust and reproducible results underline the potential of preferential crystallization to resolve co-crystal systems. |
| Keywords: | Co-crystal Conglomerate Hydrate Preferential crystallization |