超高效液相色谱?四极杆?飞行时间质谱对含PET食品接触材料中可迁移非挥发性物质的筛查研究

采用超高效液相色谱?四极杆?飞行时间高分辨质谱（UPLC?Q?TOF）对4类不同类型的含聚对苯二甲酸乙二醇酯（PET）材质的食品接触材料在4 %乙酸和50 %乙醇模拟物中的迁移出的非挥发性未知物进行筛查解析。结果表明，产品在4 %乙酸模拟物的迁移风险远小于50 %乙醇模拟物，主要迁移物质为聚合单体形成的寡聚物，抗氧剂、润滑剂、胶黏剂等加工助剂以及生产加工、迁移过程中形成的非有意添加物（NIAS）物质；纯PET材质的产品迁移物质较少，多层复合材料迁移物质较多。复合材质的产品中，PET材质可能在生产时添加了己二酸、癸二酸、新戊二醇等物质，进行了改性处理；此外，部分迁移物质会与模拟物中的乙醇发生反应，生成新的NIAS物质。

Study on determination of migratable nonvolatile substances from PET?containing food contact materials by using ultra?high performance liquid chromatography tandem quadrupole time?of?flight high?resolution mass spectrometry screening test

Aiming to evaluate the potential migration risk substances in PET?contained food contact materials， an ultra?high performance liquid chromatography tandem quadrupole time?of?flight high?resolution mass spectrometry （UPLC?Q?TOF） was used to implement screening tests and analyze the unknown non?volatile substances migrated from four different types of PET?contained food contact materials in 4 % acetic acid and 50 % ethanol simulants. The main migration substances are oligomers formed by polymerized monomers and processing aids such as antioxidants and smooth agents， as well as the NIAS substances formed in the processing and migration processes. Pure materials such as pure PET have less migration substances， while multilayer composite materials have much more migration substances. In the food contact composite materials， the PET materials can be modified by adding adipic acid， sebacic acid， neopentyl glycol or other substances during production. In addition， some of the migrated substances may undergo alcoholysis or addition reaction with ethanol in the simulant， leading to the generation of new risk NIAS.