| Affiliation: | 1. Postgraduate Program in Food Science, State University of Maringá (UEM), 5790 Colombo Avenue, Maringá, 87020-900 PR, Brazil;2. Department of Chemistry, State University of Maringá (UEM), 5790 Colombo Avenue, Maringá, 87020-900 PR, Brazil;3. Department of Chemical Engineering, State University of Maringá (UEM), 5790 Colombo Avenue, Maringá, 87020-900 PR, Brazil;4. Department of Medicine, State University of Maringá (UEM), 5790 Colombo Avenue, Maringá, 87020-900 PR, Brazil;5. Department of Physics, State University of Maringá (UEM), 5790 Colombo Avenue, Maringá, 87020-900 PR, Brazil;6. Department of Physics, State University of São Paulo (UNESP), 305 Roberto Simonsen Street, 19060-900 Presidente Prudente, SP, Brazil;7. Department of Physics, State University of Maringá (UEM), 5790 Colombo Avenue, Maringá, 87020-900 PR, Brazil
Department of Morphological Sciences, State University of Maringá (UEM), 5790 Colombo Avenue, Maringá, 87020-900 PR, Brazil |
| Abstract: | The application of fibers associated with drugs is a promising alternative to meet the clinical needs of tissue repair. Curcumin exhibits great cicatricial potential because it has numerous pharmacological properties. This research aimed to produce fibers of polycaprolactone and copolymer F-108 associated with curcumin and to evaluate in vivo their action on the process of wound healing. The fibers were produced by electrospinning technique and characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), and fluorescence microscopy. They were applied in cutaneous wounds of rats for the analysis of photoacoustic permeation and histological study. The characterization showed that the electrospinning allowed the preparation of homogeneous material with curcumin. The fibers benefited healing of the wounds and allowed the permeation of curcumin at all stages. The use of PCL/F-108 fibers allowed the elaboration of a new curcumin delivery system, improving its bioavailability and action in the healing of excisional wound. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48415. |
