基于平衡理论的模拟移动床工艺参数鲁棒寻优

在模拟移动床的实际工作过程中，由于进料浓度和温度变化以及色谱柱填充不一致等因素影响，初始工艺参数作业下的分离性能可能会出现下降。首先对模拟移动床的机理模型进行了分析；然后在色谱分离平衡理论的基础上，使用有限元正交配置法求解模型得到新的工艺参数点；最后以果葡糖浆组分分离为对象，使用所提方法求解有扰动作用时的优化工艺参数，结果显示果糖纯度的合格率从81%提高到99%，证明其具有良好的鲁棒性。

Robust optimization of process parameters of simulated moving bed based on equilibrium theory

In the actual working process of the simulated moving bed, due to the influence of factors such as the feed concentration and temperature change and the inconsistent packing of the chromatographic column, the separation performance under the operation of the initial process parameters may be reduced. The paper first analyzed the mechanism model of the simulated moving bed. Then based on the equilibrium theory of chromatographic separation, a new process parameters point is obtained by using the orthogonal collocation on finite elements method. Finally, taking the separation of fructose syrup as the object, the optimized process parameters under disturbed operation were obtained by the proposed method. The results show that the pass rate of fructose purity increased from 81% to 99%, which proved that the method has good robustness.