| 不对称合成(R)-2-羟基-4-苯基丁酸乙酯的动力学 |
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| 引用本文： | 夏涛,任其龙,吴平东.不对称合成(R)-2-羟基-4-苯基丁酸乙酯的动力学[J].化工学报,2006,57(1):46-51. |
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| 作者姓名： | 夏涛 任其龙 吴平东 |
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| 作者单位： | 浙江大学二次资源化工国家专业实验室，浙江 杭州 310027 |
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| 摘 要： | 采用10,11-二氢辛可尼定修饰的Pt/Al2O3催化体系，不对称加氢合成(R)-2-羟基-4-苯基丁酸乙酯，研究了各因素影响反应速率和光学收率的一般规律.根据推测的机理，建立了未修饰体系中加氢反应的本征动力学模型，结合实验数据选定了较佳的模型.假设不对称加氢反应总速率包括反应物在催化剂表面修饰位上和未修饰位上两部分的加氢速率，建立了不对称加氢的动力学模型，经拟合得到参数并进行了验证和讨论.
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| 关 键 词： | 不对称加氢 (R)-2-羟基-4-苯基丁酸乙酯 本征动力学 |
| 文章编号： | 0438-1157（2006）01-0046-06 |
| 收稿时间： | 12 20 2004 12:00AM |
| 修稿时间： | 2004-12-202005-03-30 |
Kinetics of enantioselective hydrogenation to synthesize ethyl (R)-2-hydroxy-4-phenylbutyrate |
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| XIA Tao,REN Qilong,WU Pingdong.Kinetics of enantioselective hydrogenation to synthesize ethyl (R)-2-hydroxy-4-phenylbutyrate[J].Journal of Chemical Industry and Engineering(China),2006,57(1):46-51. |
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| Authors: | XIA Tao REN Qilong WU Pingdong |
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| Affiliation: | State Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China |
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| Abstract: | The effects of substrate concentration, modifier amount, hydrogen pressure and temperature on initial hydrogenation rate and enantiometric excess were investigated to synthesize ethyl (R)-2-hydroxy-4-phenylbutyrate over Pt/Al_2O_3 modified by 10,11-dicinchonidine. Based on the proposed mechanism, kinetic models were established for the enantioselective hydrogenation and the parameters were estimated by fitting the experimental data. A rational model, which could describe the reaction well, was determined. |
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| Keywords: | enantioselective hydrogenation ethyl (R)-2-hydroxy-4-phenylbutyrate intrinsic kinetics |
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