| 维生素A生物合成的研究进展 |
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| 引用本文： | 王欣慧,王颖,姚明东,肖文海.维生素A生物合成的研究进展[J].化工学报,2022,73(10):4311-4323. |
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| 作者姓名： | 王欣慧 王颖 姚明东 肖文海 |
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| 作者单位： | 1.天津大学化工学院，天津 300072;2.天津大学合成生物学前沿科学中心和系统生物工程教育部重点实验室，天津 300072;3.天津大学前沿技术研究院，天津 301700 |
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| 基金项目： | 国家重点研发计划项目(2018YFA0900702) |
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| 摘 要： | 维生素A是维持人体代谢的必需维生素，在食品、药品及护肤品等多个领域占有重要地位，是三大维生素支柱产品之一，应用前景广阔。市场上的维生素A主要来源于化学合成和天然提取。近年来，随着绿色生物制造的发展，维生素A的生物合成研究取得了重大的进展。总结了维生素A生物合成的研究现状，并对维生素A生物合成的优化改造方案进行了分析归纳，概述了维生素A发酵生产以及产品组分调控和储存策略，最后对生物合成维生素A的现状进行总结与展望。
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| 关 键 词： | 维生素A 细胞工厂 合成生物学 视黄醇 酶 代谢 |
| 收稿时间： | 2022-06-15 |
Research progress of vitamin A biosynthesis |
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| Xinhui WANG,Ying WANG,Mingdong YAO,Wenhai XIAO.Research progress of vitamin A biosynthesis[J].Journal of Chemical Industry and Engineering(China),2022,73(10):4311-4323. |
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| Authors: | Xinhui WANG Ying WANG Mingdong YAO Wenhai XIAO |
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| Affiliation: | 1.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;2.Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China;3.Frontier Technology Research Institute, Tianjin University, Tianjin 301700, China |
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| Abstract: | Vitamin A is an essential vitamin to maintain human metabolism. It plays an important role in many fields such as food, medicine and skin care products, and is one of the three pillar vitamins with broad application prospects. Vitamin A on the market mainly comes from chemical synthesis and natural extraction. In recent years, with the development of green biomanufacturing, the biosynthesis of vitamin A has made great progress. This review firstly summarized the research status of vitamin A biosynthesis, analyzed and summarized the optimization of vitamin A biosynthesis, then summarized the fermentation production of vitamin A, regulation of product components and storage strategies, and finally summarized and prospected the status quo of vitamin A biosynthesis. |
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| Keywords: | vitamin A cell factory synthetic biology retinol enzyme metabolize |
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