木脂素的生物合成及其微生物法生产的研究进展

木脂素是一类分布于植物中的次级代谢产物，由两分子苯丙素衍生物聚合而成。木脂素具有抗细菌、抗病毒和抗真菌活性，被广泛用于药物和食品中。目前，木脂素的生产主要依赖于植物提取。植物生长周期长、木脂素含量低等问题，限制了木脂素的商业应用。随着木脂素合成路径和关键酶的不断解析，木脂素的生物催化合成过程受到了越来越多的关注。本文总结了典型木脂素的生物活性、生物合成路径和微生物法生产的研究进展，可以为深入研究木脂素的微生物合成提供参考。

Research progress of lignans biosynthesis and their microbial production

Lignans are a class of secondary metabolites distributed in plants, which are formed by the polymerization of two molecules of phenylpropanine derivatives. Lignans have antibacterial, antiviral and antifungal activities, and are widely used in medicine and food. At present, lignans production mainly depends on plant extraction. The commercial application of lignans is limited by the problems of long plant growth period and low content. With the continuous demonstration of lignans biosynthesis pathways and key enzymes, biocatalytic synthesis of lignans has attracted more and more attention. In this review, the biological activity, biosynthesis pathway and microbial production of typical lignans were summarized, which may provide reference for the investigation of microbial synthesis of lignans.