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| 克林霉素磷酸酯生产工艺中膜浓缩技术的研究 | |
| 引用本文： | 孙国伟,姜忠义,苏延磊,李九军,吴春虎,王伟龙.克林霉素磷酸酯生产工艺中膜浓缩技术的研究[J].河北化工,2007,30(6):52-54. |
| 作者姓名： | 孙国伟 姜忠义 苏延磊 李九军 吴春虎 王伟龙 |
| 作者单位： | 1. 天津大学化工学院,天津,300072;华北制药集团公司,河北,石家庄,050015 2. 天津大学化工学院,天津,300072 3. 华北制药集团公司,河北,石家庄,050015 |
| 摘 要： | 针对克林霉素磷酸酯(CLP)工业生产过程中解吸液的组分特性和目前传统生产技术存在的问题,研究了用膜浓缩替代蒸发浓缩的可行性和实用性,重点考察了膜材质和操作温度、操作压力等对纳滤的分离性能的影响,优化了工艺条件.结果表明,用复合膜、压力在1.5 MPa左右、温度为55℃左右进行纳滤浓缩得到的CLP质量优于传统工艺. |
| 关 键 词： | 纳滤 浓缩 克林霉素磷酸酯 膜分离 |
| 文章编号： | 1003-5095（2007）06-0052-03 |
| 修稿时间： | 2007-04-11 |
Research on Technology of Membrane Condensation in the Production Process of Clindamycin Phosphate |
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| SUN Guo-wei,JIANG Zhong-yi,SU Yan-lei,LI Jiu-jun,WU Chun-hu,WANG Wei-long.Research on Technology of Membrane Condensation in the Production Process of Clindamycin Phosphate[J].Hebei Chemical Engineering and Industry,2007,30(6):52-54. | |
| Authors: | SUN Guo-wei JIANG Zhong-yi SU Yan-lei LI Jiu-jun WU Chun-hu WANG Wei-long |
| Affiliation: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;2. North China PharmaceuticalCo., Ltd, Shijiazhuang 050015, China |
| Abstract: | This paper presents that the desorption solution of clindamycin phosphate(CLP).was treated by nanofiltration.Results indicated that the desorption solution of CLP could be concentrated by nanofiltration membrane,the different membrane and operation condition such as temperature,pressure had an important influence on separation characteristics.The quality of CLP got by nanofiltration process was better than by traditional decompressing-distillation process. |
| Keywords: | nanofiltration concentration clindamycin phosphate membrane separation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |