| 2-氨基-5,6-二氢一苯并噻唑-7(4H)-酮的合成与表征 |
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| 引用本文： | 董明东,宫胜臣,陈启凡.2-氨基-5,6-二氢一苯并噻唑-7(4H)-酮的合成与表征[J].辽东学院学报(自然科学版),2010,17(4). |
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| 作者姓名： | 董明东 宫胜臣 陈启凡 |
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| 作者单位： | 辽东学院实验中心,辽宁,丹东,118003;辽东学院实验中心,辽宁,丹东,118003;辽东学院实验中心,辽宁,丹东,118003 |
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| 摘 要： | 以1,3-环己二酮(Ⅰ)为原料,在水相中与溴进行溴化反应制备2-溴-1,3-环己二酮(Ⅱ),产物未经提纯,直接将II与硫脲在乙醇介质中回流反应6 h合成了目标产物2-氨基-5,6-二氢-苯并噻唑-7(4H)-酮(Ⅲ),总收率为74%,合成产品通过乙醇重结晶进行了纯化,并通过核磁共振氢谱进行了结构确证。
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| 关 键 词： | 1 3-环己二酮 溴化 2-氨基噻唑 合成 |
Synthesis and Characterization of 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one |
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| DONG Ming-dong,GONG Sheng-chen,CHEN Qi-fan.Synthesis and Characterization of 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one[J].Journal of Liaodong University：Natural Sciences,2010,17(4). |
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| Authors: | DONG Ming-dong GONG Sheng-chen CHEN Qi-fan |
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| Affiliation: | DONG Ming-dong,GONG Sheng-chen,CHEN Qi-fan(Experimental Center,Eastern Liaoning University,Dandong 118003,China) |
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| Abstract: | 2-Bromo-1,3-Cyclohexanedione(Ⅱ) was prepared with 1,3-Cyclohexanedione(Ⅰ) as the initial reactant that was brominated via bromine in aqueous phase.Further more,2-amino-5,6-dihydrobenzod]thiazol-7(4H)-one(Ⅲ) was prepared by the six-hour reflux reaction of Bromo-1,3-Cyclohexanedione(II) and thiourea in ethanol medium at 80 ℃.The yield was 74%.The synthetic products were purified through re-crystallization.Finally,the structure of these products was characterized by 1HNMR. |
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| Keywords: | 1 3-Cyclohexanedione bromination 2-Amino-thiazole synthesis |
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