2,3,4-三氟硝基苯的合成改进

介绍了用2,4-二氯-3-氟硝基苯与氟化钾经卤素置换反应合成2,3,4-三氟硝基苯的方法,讨论了2,4-二氯-3-氟硝基苯的合成条件-水分、催化剂、反应温度等因素对反应收率的影响,用高沸点的环丁砜代替原来的二甲基亚砜作溶剂,用苯脱除反应介质中的水分,确保反应在无水体系中进行,单步收率达到78 1%,总收率提高到55 3%。

Improvement of Synthesis of 2,3,4-Trifluoronitrobenzene

2,3,4-trifluoronitrobenzene was synthesized from 2,4-dichloro-3-fluoronitrobenzene and potassium fluoride via halogen replacement reaction.The optimization of synthetic conditions of 2,3,4-trifluoronitrobenzene was studied,such as the effect of water content,catalyst and reaction temperature on yield.The customary solvent of dimethylsolfoxide was replaced by the high boiling point solvent of sulfolane.The water content in the reaction medium was removed with benzene and the reaction was completed in the anhydrous system.The single step yield of 78.1% and the overall yield of 55.3% were obtained.