| 灵芝三萜类成分抑制拓扑异构酶Ⅰ活性的研究 |
| |
| 引用本文： | 唐文.灵芝三萜类成分抑制拓扑异构酶Ⅰ活性的研究[J].上海轻工业高等专科学校学报,2011(2):90-94. |
| |
| 作者姓名： | 唐文 |
| |
| 作者单位： | 上海应用技术学院香料香精技术与工程学院,上海200235 |
| |
| 基金项目： | 上海市教委科研创新项目（09Y2393） |
| |
| 摘 要： | 以灵芝中的三萜类组分（灵芝酸T）为实验药物,考察其对拓扑异构酶Ⅰ活性的影响。结果表明：灵芝酸T能抑制拓扑异构酶Ⅰ活性,且具有浓度依赖性。进一步机理研究表明灵芝酸T可以抑制拓扑异构酶-底物复合物的形成,阻止DNA和酶的相互作用。因此,灵芝酸T属于拓扑异构酶Ⅰ的催化型抑制剂,这可为灵芝中三萜类物质的研究开发提供理论依据。
|
| 关 键 词： | 灵芝酸 拓扑异构酶 抑制作用 |
The Inhibition Effect of Triterpenoid in Ganoderma on Topoisomerase Ⅰ |
| |
| TANG Wen.The Inhibition Effect of Triterpenoid in Ganoderma on Topoisomerase Ⅰ[J].Journal of Shanghai Institute of Technology(Natural Science),2011(2):90-94. |
| |
| Authors: | TANG Wen |
| |
| Affiliation: | TANG Wen (School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 200235, China) |
| |
| Abstract: | The triterpenoids components in ganoderma as experimental material were examined on the effect of activity of topoisomerase Ⅰ. The data showed that ganoderic acid T inhibited the activity of topoisomerase Ⅰ behaviors the dose-dependent manner. The inhibition mechanism exploration showed that ganoderic acid T could block the interaction of DNA and topoisomerase Ⅰ by inhibiting the complex formation of the substitute and topoisomerase Ⅰ. The results indicated that ganoderic acid T is a kind of catalysis inhibitor. |
| |
| Keywords: | ganoderic acid topoisomerase Ⅰ inhibition |
| 本文献已被 维普 等数据库收录！ |
