| 西草净合成工艺研究(Ⅰ) |
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| 引用本文： | 薛连海,辛世崇,遇万钧,张连春.西草净合成工艺研究(Ⅰ)[J].吉林化工学院学报,2005,22(4):4-6. |
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| 作者姓名： | 薛连海 辛世崇 遇万钧 张连春 |
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| 作者单位： | 吉林化工学院,制药与应用化学系,吉林,吉林,132022;吉林化工学院,制药与应用化学系,吉林,吉林,132022;吉林化工学院,制药与应用化学系,吉林,吉林,132022;吉林化工学院,制药与应用化学系,吉林,吉林,132022 |
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| 摘 要： | 以三聚氯氰、乙胺和甲硫醇钠为原料,以三氯乙烯为溶剂(V)制备了西草净.讨论了原料配比、反应时间和反应温度等因素对反应的影响,获得了适宜的反应条件.适宜反应条件为三聚氯氰:乙胺:氢氧化钠:甲硫醇钠=1∶2.1∶2.1∶4(摩尔比),第一、第二、第三取代反应的反应温度和反应时间分别为0,20,78℃和10,30,480 min.在适宜的反应条件下,西草净的收率和纯度分别为73.57%和89.52%.
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| 关 键 词： | 适宜 西草净 合成 |
| 文章编号： | 1007-2853（2005）04-0004-03 |
| 收稿时间： | 2005-07-18 |
| 修稿时间： | 2005年7月18日 |
Study on the synthesis simetryne |
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| XUE Lian-hai,XIN Shi-cong,YU Wan-jun,ZHANG Lian-chun.Study on the synthesis simetryne[J].Journal of Jilin Institute of Chemical Technology,2005,22(4):4-6. |
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| Authors: | XUE Lian-hai XIN Shi-cong YU Wan-jun ZHANG Lian-chun |
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| Affiliation: | Dept. of Pharmacy and Applied Chemistry, Jilin Institute of Chemical Technology,Jilin City 132022, China |
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| Abstract: | Simetryne is synthesized from cyanuric chloride,ethylamine and sodium methyl mercaptide in solution of the trichloroethylene.The effects of some factor such as reaction ratio,reaction time and reaction temperature on the reaction are investigated.The appropriate reaction conditions are obtained.The appropriate conditions are that the mole ratio of cyanuric chloride to ethylamine,sodium hydroxide,sodium methyl mercaptide is 1∶ 2.1∶ 2.1∶:4.0,the temperature and time of first,second,third substitution reaction is respectively 0℃,20℃,78℃ and 10min,30min,480min.The yield and purity of simetryne reach 73.57% and 89.52% respectively under appropriate reaction conditions. |
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| Keywords: | appropriate simet ryne synthesis |
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