| 溶剂法制备阿司匹林缓释固体分散体中载体对药物溶出度的影响 |
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| 引用本文： | 金刚,王洁,于世华,张艳,曲小姝,刘治刚.溶剂法制备阿司匹林缓释固体分散体中载体对药物溶出度的影响[J].吉林化工学院学报,2014,31(9):28-30. |
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| 作者姓名： | 金刚 王洁 于世华 张艳 曲小姝 刘治刚 |
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| 作者单位： | 1. 吉林化工学院化学与制药工程学院,吉林吉林,132022
2. 吉林化工学院分析测试中心,吉林吉林,132022 |
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| 摘 要： | 目的:采用溶剂法制备阿司匹林缓释固体分散体,并考查载体对药物体外溶出速度的影响.方法:分别选用乙基纤维素(EC)、羟丙甲基纤维素(HPMC)及甲基纤维素(MC)为辅料,通过测定阿司匹林在各种辅料水溶液的溶解度及固体分散体在水中的溶出度选择最优载体,来制备阿司匹林缓释固体分散体.结果:当选择EC和HPMC为共同载体,且药物:EC:HPMC的比例为1 7 0.7时,药物在2、6、12 h分别能溶出至30%、50%、80%左右,对药物可起到很好的缓释效果.
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| 关 键 词： | 固体分散体 缓释 阿司匹林 体外溶出度 |
The Effect of Dissolution Rate for the Carriers in the Sustained Release Solid Dispersion of Aspirin Prepared by Solvent Method |
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| JIN Gang,WANG Jie,YU Shi-hua,ZHANG Yan,QU Xiao-shu,LIU Zhi-gang.The Effect of Dissolution Rate for the Carriers in the Sustained Release Solid Dispersion of Aspirin Prepared by Solvent Method[J].Journal of Jilin Institute of Chemical Technology,2014,31(9):28-30. |
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| Authors: | JIN Gang WANG Jie YU Shi-hua ZHANG Yan QU Xiao-shu LIU Zhi-gang |
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| Affiliation: | JIN Gang;WANG Jie;YU Shi-hua;ZHANG Yan;QU Xiao-shu;LIU Zhi-gang;College of Chemical and Pharmaceutical Engineering,Jilin Institute of Chemical Technology;Analysis and Test Center,Jilin Institute of Chemical Technology; |
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| Abstract: | Objective： Solvent method is used to prepare the sustained release solid dispersions of aspirin and the effect of carriers for dissolution rate of the drug is checked. Methods ： Sustained release solid dispersions of aspirin have been prepared with EC, HPMC, MC, respectively. Then the optimal materials and the ratio from the solubility and dissolution test are chosen. Conclusion： The dissolution rate of drug was 30% ,50% ,80% at 2,6,12 h,when chosing the EC and HPMC as the cocarriers and the ratio of the drug： EC： HPMC was 1：7 ： 0.7. The solid dispersion has a better sustained release effect for the drug. |
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| Keywords: | solid dispersion sustained release aspirin in vitro dissolution |
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