| PEG的分子量对PPC缓释膜片体外动态释放速率影响的研究 |
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| 引用本文： | 万昌秀,段友容,吴刚,樊翠容,钟银屏,乐以伦.PEG的分子量对PPC缓释膜片体外动态释放速率影响的研究[J].四川大学学报(工程科学版),2000,32(2):51-54. |
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| 作者姓名： | 万昌秀 段友容 吴刚 樊翠容 钟银屏 乐以伦 |
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| 作者单位： | 四川大学,高分子材料科学与工程系,成都,610065 |
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| 基金项目： | 四川省科委应用基础研究项目!川科委计 ( 1997) 0 16 |
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| 摘 要： | 研究了成孔剂ＰＥＧ的分子量对ＰＰＣ缓释膜片体动态释速率的影响。用蒸馏水为缓释液，在振荡条件下对ＰＰＣ膜片进行了体外释放。结果表明：当ＰＥＧ分子量小于１０００时，随着分子量增加，其药物释放速度加快；当分子量超过１０００时，随着分子量增加，其药物释放速度反而降低。
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| 关 键 词： | 生物材料 PEG 分子量 PPC缓释膜片 释放速率 |
| 修稿时间： | 1998-12-30 |
Study of Effect of Various Molecular weight PEG on Controlled Release Rates of PPC Film in Vitro |
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| WAN Chang-xiu,DUAN You-rong,WU Gang,FAN Cui-rong,ZHONG Yin-ping,YUE Yi-lun.Study of Effect of Various Molecular weight PEG on Controlled Release Rates of PPC Film in Vitro[J].Journal of Sichuan University (Engineering Science Edition),2000,32(2):51-54. |
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| Authors: | WAN Chang-xiu DUAN You-rong WU Gang FAN Cui-rong ZHONG Yin-ping YUE Yi-lun |
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| Abstract: | This experiment studied the effecting of Pore former PEG varies molecular to heterogeneous ciprofloxacin matrix system PPC(PU,PEG,Ciprofloxacin)releasing rates. The releasing rates of ciprofloxacin of PPC matrix into deionized water at room temperrature under shaking operated at 86 RPM to ensure good mixing with a shaker device was studied.The results indicated that the releasing rates increaed with PEG molecular increaing when PEG molecular under 10000,and the releasing rates decreased with PEG molecular increaing when PEG molecular exceeding 10000. |
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| Keywords: | antibiosis control release biomaterials |
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