| Intercalation of Amido Cationic Drug with Montmorillonite |
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| 作者姓名： | 郑俊萍 |
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| 作者单位： | School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China |
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| 摘 要： | The intercalation of drug molecules with montmorillonit （MMT） using Acyclovir （ACV） as the model drug was focused on. The optimum conditions were studied based on orthogonal design, such as intercalation time and temperature. The intercalation composites were characterized by X-ray diffraction （XRD）, Fourier transformed infrared （FT-IR）, and thermogravimetric analysis （TGA）. The experimental results reveal that ACV is successfully intercalated into the interlayers of MMT, The in vitro release experiments reveal that ACV is released from MMT steadily and pH dependent.
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| 关 键 词： | 蒙脱石 插层复合物 酰胺阳离子 药物分子 |
| 收稿时间： | 19 March 2005 |
| 修稿时间： | 2005-03-192006-01-17 |
Intercalation of amido cationic drug with montmorillonite |
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| Zheng?Junping,Wang?Hongyan,Zhuang?Hong,Xi?Lifei,Yao?Kangde.Intercalation of Amido Cationic Drug with Montmorillonite[J].Journal of Wuhan University of Technology. Materials Science Edition,2007,22(2):250-252. |
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| Authors: | Zheng Junping Wang Hongyan Zhuang Hong Xi Lifei Yao Kangde |
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| Affiliation: | School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China |
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| Abstract: | The intercalation of drug molecules with montmorillonit(MMT)using Acyclovir(ACV) as the model drug was focused on.The optimum conditions were studied based on orthogonal design,such as intercalation time and temperature.The intercalation composites were characterized by X-ray diffraction(XRD),Fourier transformed infrared(FT-IR),and thermogravimetric analysis(TGA).The experimental results reveal that ACV is successfully intercalated into the interlayers of MMT.The in vitro release experiments reveal that ACV is released from MMT steadily and pH dependent |
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| Keywords: | montmorillonite acyclovir intercalation in vitro release |
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