| Abstract: | Magnetic fluorescent dual-drug nanocomposites(MFDDs) were developed with the aim of simultaneouly delivering two different anticancer drugs, kaempferol(KAE) and paclitaxel(PTX). Firstly, Fe_3O_4/bovine serum albumin(Fe_3O_4/BSA) composite microspheres with physically entrapped KAE were prepared, then microspheres were modified with PTX/graphene quantum dots(PTX/GQDs) through chemically bonding, and the MFDDs were obtained. The properties of nancomposites were characterized by X-ray diffractometry, Fourier-transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometry and X-ray fluorescence spectrometry. It was found that the superparamagnetic nanocomposites had ultrafine size(below 110 nm), high saturation magnetization of 24.36 emu/g, and significant fluorescence. Furthermore, the cumulative in vitro release of the MFDDs exhibited controlled drug release. Cell viability experiments confirmed that the co-administration of KAE with PTX had a superior cytotoxicity to the Hela cells compared with single drug-loaded forms. Therefore, dual anticancer drug-loaded MFDDs have the potential to be used for cancer combined chemotherapy. |
