| Observing Intratissuelar Distribution of Polysorbate 80 Coated Nanoparticles in Brain with Analytical Electron Microscopy |
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| 作者姓名： | 孙望强 杨祥良 |
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| 作者单位： | Institute of Material Medical College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China，Department of Materials Science and Engineering Huazhong University of Science and Technology，Wuhan 430074 China，Institute of Material Medical College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China |
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| 基金项目： | FundedbytheNationalNaturalScienceFoundationofChina(No.30170392and50271029) |
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| 摘 要： | 1Introduction Theblood brainbarrier(BBB)representsaninsur mountableobstacle,whichhinderswater solublemole culesandthosewithmolecularweightabove500,suchas thetherapeuticpeptides,proteins,genesandantibiotics,fromthecircularsystemtothebrain16].Itwasreported…
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Observing Intratissuelar Distribution of Polysorbate 80 Coated Nanoparticles in Brain with Analytical Electron Microscopy |
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| SUN Wangqiang , WANG Huafang XIE Changsheng HU Yu YANG Xiangliang XU Huibi.Observing Intratissuelar Distribution of Polysorbate 80 Coated Nanoparticles in Brain with Analytical Electron Microscopy[J].Journal of Wuhan University of Technology. Materials Science Edition,2005,20(Z1). |
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| Authors: | SUN Wangqiang WANG Huafang XIE Changsheng HU Yu YANG Xiangliang XU Huibi |
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| Affiliation: | SUN Wangqiang 1,2 WANG Huafang3 XIE Changsheng2 HU Yu3 YANG Xiangliang 1 XU Huibi1 |
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| Abstract: | The analytical electron microscopy (AEM) was employed to observe the intratissuelar distribution of polysorbate 80 coated nanoparticles in brain with copper chlorophyll (CC), and a safe and cheap pigment was used as a marker. AEM analyses show that some nanoparticles are located at the wall of the microvasculum in brain, while others are distributed around the microvasculum in brain. These results may support that T-80 coated nanoparticles cross the BBB through mechanisms of endocytosis or transcytosis. |
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| Keywords: | nanoparticles blood-brain barrier copper chlorophyll analytical electron microscopy |
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