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负载食管癌抗原肽的脐血树突状细胞诱导杀瘤活性研究
引用本文:王健,史玉,苏安英,柴锡庆,门金娥,郑海萍,张向阳,田珂. 负载食管癌抗原肽的脐血树突状细胞诱导杀瘤活性研究[J]. 河北工程大学学报(自然科学版), 2008, 25(2): 95-97
作者姓名:王健  史玉  苏安英  柴锡庆  门金娥  郑海萍  张向阳  田珂
作者单位:河北工程大学教务处 河北邯郸056038
摘    要:为探讨负载酸洗脱食管癌抗原肽的脐血树突状细胞(DCs)对细胞毒T细胞(CTL)杀伤活性的影响,本研究采用密度梯度离心法分离脐血中的单个核细胞(CBMNC),在重组人粒巨噬细胞集落刺激因子(rhGM-CSF)、重组白介素(rhIL-4)及重组肿瘤坏死因子(rhTNF-a)的配伍作用下,以酸洗脱食管癌抗原肽负载获得分化成熟DCs,利用CytoTox 96试剂盒检测其对特异性CTL的诱导和体外杀伤效应的影响。结果:负载食管癌抗原肽的脐血DCs诱导的CTL对酸洗前食管癌细胞株T.Tn的杀伤率达(78.5±9.5)%,显著高于酸洗后组和各对照组(P<0.05),而对无关肿瘤细胞株Hep2无显著杀伤作用(P<0.05)。结论:负载食管癌抗原肽的脐血DCs体外可诱导CTL产生特异性杀伤效应。本研究为食管癌的免疫治疗提供了新的有效途经。

关 键 词:树突状细胞  食管癌  细胞毒性T淋巴细胞  脐血
收稿时间:2008-03-24

Research of human cord blood dendritic cells loaded with peptides of esophageal carcinoma cells on cytotoxicity activity
WANG Jian,SHI Yu,SU An-ying,CHAI Xi-qing,MEN Jin-e,ZHENG Hai-ping,ZHANG Xiang-yang and TIAN Ke. Research of human cord blood dendritic cells loaded with peptides of esophageal carcinoma cells on cytotoxicity activity[J]. Journal of Hebei University of Engineering(Natural Science Edition), 2008, 25(2): 95-97
Authors:WANG Jian  SHI Yu  SU An-ying  CHAI Xi-qing  MEN Jin-e  ZHENG Hai-ping  ZHANG Xiang-yang  TIAN Ke
Affiliation:Department of Educational Administration,Hebei University of Engineering,Handan 056038,China;Department of Educational Administration,Hebei University of Engineering,Handan 056038,China;Department of Educational Administration,Hebei University of Engineering,Handan 056038,China;Department of Educational Administration,Hebei University of Engineering,Handan 056038,China;Department of Educational Administration,Hebei University of Engineering,Handan 056038,China;Department of Educational Administration,Hebei University of Engineering,Handan 056038,China;Department of Educational Administration,Hebei University of Engineering,Handan 056038,China;Department of Educational Administration,Hebei University of Engineering,Handan 056038,China
Abstract:
Keywords:dendritic cells  esophageal carcinoma  cytotoxic T lymphocyte  cord blood
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