N－（4－苯甲氰基）－3－氯苯甲酰胺的合成工艺研究

为了得到合成 N－（4－苯甲氰基）－3－氯苯甲酰胺的最优条件，以3－氯苯甲酸和4－硝基苯甲腈为起始原料，经还原、酰氯化、酰胺化合成 N－（4－苯甲氰基）－3－氯苯甲酰胺，考察不同反应条件对产品收率的影响。实验结果表明，得出最佳反应条件为：3－氯苯甲酸与4－氨基苯甲腈物料比1∶1．15，滴加过程控温0～5℃，缚酸剂：DIEA，用量为胺的2倍量，反应2 h，产品收率为89％。得出结论：建立了一种合成 N－（4－苯甲氰基）－3－氯苯甲酰胺的合成路线，该合成路线反应条件温和、工艺操作简便、容易控制。

The Synthesis of 3-Chloro-N-(4-Cyanophenyl) Benzamide

To get an optimal condition for the synthesis of 3-chloro-N-( 4-cyanophenyl) benzamide,3-chloro-N-( 4-cyanophenyl) benzamide was synthesized from 4-nitrobenzonitrile and 3-chlorobenzoic acid by reduction, chloride, amide.The effect of different reaction conditions on product yield was investigated.The target compound could be obtained in 89% by the best condition: 3-chloro-benzoic acid with 4-aminobenzonitrile material ratio of 1∶1.15, dropping temperature 0 ~5 ℃, acid binding agent: N,N-Diisopropylethylamine, in an amount of 2-times amount of amine,reaction for two hours.A synthesis route was established for the synthesis of 3-chloro-N-(4-cyanophenyl) benzamide, the synthetic route is in mild reaction conditions, the process is simple to operate, easy to control.