| 无催化剂条件下二氢吡啶酯还原醛亚胺的研究 |
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| 引用本文： | 王周玉,何其,冯华林,赵艳梅,王驹,刘丽.无催化剂条件下二氢吡啶酯还原醛亚胺的研究[J].西华大学学报(自然科学版),2013(5):18-21,25. |
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| 作者姓名： | 王周玉 何其 冯华林 赵艳梅 王驹 刘丽 |
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| 作者单位： | 西华大学化学系;西华大学制药工程系 |
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| 基金项目： | 国家自然科学基金(21102115);西华大学天然药物研究与工程校重点实验室(XZD0821-09-1) |
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| 摘 要： | 用二氢吡啶酯为还原剂,在无催化剂条件下对醛亚胺的还原进行了研究,考察了溶剂、温度、二氢吡啶酯与亚胺的摩尔比例以及添加剂对反应的影响。同时,在最优条件下对一系列N-芳基醛亚胺进行了还原,最高收率可以达到99%。
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| 关 键 词： | 无催化剂 二氢吡啶酯 醛亚胺 还原 |
Reduction of Aldimines with Hantzsch Esters in Absence of Catalysts |
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| WANG Zhou-yu;HE Qi;FENG Hua-lin;ZHAO Yan-mei;WANG Ju;LIU Li.Reduction of Aldimines with Hantzsch Esters in Absence of Catalysts[J].Journal of Xihua University:Natural Science Edition,2013(5):18-21,25. |
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| Authors: | WANG Zhou-yu;HE Qi;FENG Hua-lin;ZHAO Yan-mei;WANG Ju;LIU Li |
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| Affiliation: | WANG Zhou-yu;HE Qi;FENG Hua-lin;ZHAO Yan-mei;WANG Ju;LIU Li;Department of chemistry,Xihua University;Department of Pharmaceutical Engineering,Xihua University; |
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| Abstract: | In absence of any additional catalysts, reduction of aldimines with Hantzsch esters is studied in the paper. The effects of solvent, temperature, the ratio of Hantzsch esters and imines, the additives are investigated. Under the optimal conditions, a series of N-aromatic aldimines are reduced with Hantzscb esters. The isolated yield is up to 99%. |
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| Keywords: | catalyst-free reduction aldimines hantzsch ester |
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