| Enantioselective extraction of clorprenaline enantiomers with hydrophilic selector of sulfobutylether-β-cyclodextrin by experimentand modeling简 |
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| 引用本文： | 周从山,徐萍,唐课文,蒋新宇,杨涛,张盼良,朱政.Enantioselective extraction of clorprenaline enantiomers with hydrophilic selector of sulfobutylether-β-cyclodextrin by experimentand modeling简[J].中南工业大学学报(英文版),2014(3):891-899. |
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| 作者姓名： | 周从山 徐萍 唐课文 蒋新宇 杨涛 张盼良 朱政 |
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| 基金项目： | Projects（21176262, 21071052） supported by the National Natural Science Foundation of China; Project supported by the Aid program for Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China; |
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| 摘 要： | Enantioselective extraction of hydrophobic clorprenaline （CPE） enantiomers from organic phase to aqueous phases with sulfobutylether-β-cyclodextrin （SBE-β-CD） as the selector was investigated with insight into a number of important process variables, such as the type of organic solvent, concentration of selector, pH, and temperature. Equilibrium of the extraction system was modeled using a reactive extraction modcl with a homogeneous aqueous phase reaction. The important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic CPE were determined as 0.3 and 8.93, respectively. The equilibrium constants of the complexation reaction with SBE-β-CD were determined as 152 and 110 L/mol for R- and S-CPE, respectively. Results show that the experimental data agree with the model predictions perfectly. Comprehensively considering the experiment and model, the extraction conditions are optimized and the best extraction conditions are： pH of 6.0, SBE-β-CD concentration of 0.04 tool/L, and temperature of 5 ℃, providing the enantioselectivity （a） of 1.25, the fraction of R-CPE （φR） in aqueous phase of 0.71 and performance factor （pf） of 0.025.
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| 关 键 词： | 选择性萃取 β-环糊精 实验测定 对映体 丁基 建模 亲水 β-CD |
Enantioselective extraction of clorprenaline enantiomers with hydrophilic selector of sulfobutylether-β-cyclodextrin by experiment and modeling |
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| ZHOU Cong-shan,XU Ping,TANG Ke-wen,JIANG Xin-yu,YANG Tao,ZHANG Pan-liang,ZHU Zheng.Enantioselective extraction of clorprenaline enantiomers with hydrophilic selector of sulfobutylether-β-cyclodextrin by experiment and modeling[J].Journal of Central South University of Technology,2014(3):891-899. |
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| Authors: | ZHOU Cong-shan XU Ping TANG Ke-wen JIANG Xin-yu YANG Tao ZHANG Pan-liang ZHU Zheng |
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| Affiliation: | [1]College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414000, China [2]College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China |
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| Abstract: | clorprenaline sulfobutylether-fl-cyclodextrin reactive extraction chiral recognition modeling |
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| Keywords: | clorprenaline sulfobutylether-fl-cyclodextrin reactive extraction chiral recognition modeling |
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