| 烷基修饰SBA-15的制备及药物缓释性能研究 |
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| 引用本文： | 李莎,田金凤,张红,刘晓蒙,高云鹏,郭卓.烷基修饰SBA-15的制备及药物缓释性能研究[J].沈阳化工学院学报,2012,26(1):57-62. |
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| 作者姓名： | 李莎 田金凤 张红 刘晓蒙 高云鹏 郭卓 |
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| 作者单位： | 1. 沈阳化工大学材料科学与工程学院,辽宁沈阳,110142
2. 沈阳化工股份有限公司,辽宁沈阳,110026 |
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| 摘 要： | 用水热法制备介孔分子筛SBA-15,用三甲基氯硅烷（Trimethylchlorosilane,TMCS）对介孔分子筛SBA-15进行烷基化修饰.然后将药物布洛芬（Ibu）组装到两种材料中,用XRD、FT-IR、N2吸附、TEM等表征方法对分子筛及药物组装体进行表征,测定组装体在人工肠液中的释放行为.结果显示：SBA-15经三甲基氯硅烷修饰后,孔径减小,但仍然具有规则排列的孔道结构.这两种材料的载药体系均能实现缓释.修饰后释药速率进一步减慢,且随着三甲基氯硅烷接枝量的增加释药速率减慢,可通过三甲基氯硅烷修饰量来调节释放速率.
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| 关 键 词： | SBA-15 修饰 布洛芬 药物缓释 |
Performance of Drug Loading and Release on Trimethylchlorosilane Modified SBA-15 |
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| LI Sha,TIAN Jin-feng,ZHANG Hong,LIU Xiao-meng,GAO Yun-peng,GUO Zhuo.Performance of Drug Loading and Release on Trimethylchlorosilane Modified SBA-15[J].Journal of Shenyang Institute of Chemical Technolgy,2012,26(1):57-62. |
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| Authors: | LI Sha TIAN Jin-feng ZHANG Hong LIU Xiao-meng GAO Yun-peng GUO Zhuo |
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| Affiliation: | 1 (1.Shenyang University of Chemical Technology,Shenyang 110142,China; 2.Shenyang Chemical Co.,LTD,Shenyang 110026,China) |
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| Abstract: | In this paper,mesoporous molecular sieve SBA-15 was synthesized by hydrothermal process.At the same time,modified SBA-15 was synthesized using the Trimethylchlorosilane as functional agent.The before and after modified SBA-15 were charactered by XRD,FT-IR,Nitrogen absorption and TEM.In order to control the drug loading and release profiles,ibuprofen was dissolved in the channel of SBA-15 and modified SBA-15.The results showed that the pore size slightly decreased and the hexagonal structure of SBA-15 was still maintained after Trimethylchlorosilane modification.The release rate decreased after modification with the increase amount of Trimethylchlorosilanel. |
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| Keywords: | SBA-15 modified ibuprofen release |
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