| ns脉冲电场诱导细胞脂双层膜电穿孔的仿真分析 |
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| 引用本文： | 姚陈果,王剑飞,李成祥,米彦,孙才新.ns脉冲电场诱导细胞脂双层膜电穿孔的仿真分析[J].高电压技术,2010,36(2):423-427. |
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| 作者姓名： | 姚陈果 王剑飞 李成祥 米彦 孙才新 |
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| 作者单位： | 重庆大学输配电装备及系统安全与新技术国家重点实验室,重庆,400044 |
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| 基金项目： | 国家自然科学基金(50637020;50877083)~~ |
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| 摘 要： | 为探讨ns脉冲电场诱导细胞器膜产生电穿孔的机理,采用分子动力学软件从原子水平上分析了ns脉冲电场作用下细胞脂双层膜电穿孔形成及其孔径随时间变化的过程,研究了电穿孔形成的机理。结果表明,脂质分子的偶极子在脉冲电场作用下的振动和转动导致脂双层膜出现初始缺损并诱导脂双层膜电穿孔;电穿孔初期的多微孔间存在耦合关系;在4～5 ns内电穿孔形成并达到动态稳定。结果与细胞脂双层膜的粗粒化模型计算吻合较好,为电穿孔技术在生物医学等方面的应用提供了理论指导。
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| 关 键 词： | ns脉冲电场 电穿孔 机理 脂双层膜 分子动力学 仿真 |
Simulation Analysis of of Electroporation Induced by Intense Nanosecond Pulse Electric Field in Cell Membrane Bilayers |
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| YAO Chen-guo,WANG Jian-fei,LI Cheng-xiang,MI Yan,SUN Cai-xin.Simulation Analysis of of Electroporation Induced by Intense Nanosecond Pulse Electric Field in Cell Membrane Bilayers[J].High Voltage Engineering,2010,36(2):423-427. |
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| Authors: | YAO Chen-guo WANG Jian-fei LI Cheng-xiang MI Yan SUN Cai-xin |
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| Affiliation: | State Key Laboratory of Power Transmission Equipment & System Security and New Technology;Chongqing University;Chongqing 400044;China |
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| Abstract: | Cell membrane bilayers were simulated by molecular dynamics to probe mechanism of electroporation induced by intense nanosecond pulse electric field.The process of electroporation and its pore size in lipid bilayers were analyzed from the atomic level,and the mechanism of electroporation formation was also analyzed.Results reveal that the initial defect formation on the surface of the membrane was induced by swing and rotation of dipoles at the lipid molecules which were subjected to nanosecond,high intensi... |
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| Keywords: | nanosecond pulse electric field electroporation mechanism lipid bilayers molecular dynamics simulation |
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