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Manipulating DNA molecules in nanofluidic channels |
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| Authors: | Kai-Ge Wang Shuanglin Yue Lei Wang Aizi Jin Changzhi Gu Peng-Ye Wang Yuchun Feng Yuncheng Wang Hanben Niu |
| Affiliation: | (1) Institute of Optoelectronics, Shenzhen University, Shenzhen, 518060, China;(2) Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100080, China;(3) Laboratory for Micro-fabrication, Institute of Physics, Chinese Academy of Sciences, Beijing, 100080, China;(4) Xi’an Institute of Applied Optics, Chinese Academy of Sciences, Xi’an, 710065, China |
| Abstract: | Nanofluidic channels of ∼40×60 nm (width × depth) were fabricated with focused ion beam (FIB) milling instrument on a silicon nitride (Si3N4) film. Stained λ-phage DNA molecules were driven into these open channels by capillary force and observed with fluorescence microscopy. The movements of DNA molecule in these channels were discussed. These sub-100 nm scale channels may be useful in studying single biomacromolecules. |
| Keywords: | Nanofluidic channels DNA Fluorescence microscopy |
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