蛋白质相互作用网络功能模块检测的研究综述

蛋白质相互作用（Protein-protein interaction，PPI）网络是生命活动中一种极其重要的生物分子关系网络，利用计算方法从PPI网络中检测功能模块是目前生物信息学中一项重要的研究课题. 本文首先总结了功能模块检测过程的基本流程，说明了预处理和后处理的作用；其次，提出了一种模块检测方法的分类体系，并对其中一些代表性的检测算法进行了阐述；再次，给出了模块检测常用的数据库、评价指标和相关软件工具，并通过实验对代表性算法进行了性能对比. 最后，通过对该领域挑战性问题的分析预测了模块检测未来的研究方向，以期对相关研究提供一定的参考.

An Overview of Research on Functional Module Detection for Protein-protein Interaction Networks

As a bimolecular relationship network, the protein-protein interaction (PPI) network plays an important role in biological activities. Using computational approaches, mining functional modules from a PPI network is currently a challenge in bioinformatics. This paper firstly gives a workflow of detecting functional modules from PPI data, and illustrates the effects of preprocessing and post processing. Next, a systematic category of functional module detection is proposed, and many typical detecting algorithms in each category are described. And then, the paper lists some public databases, evaluating metrics, related software tools, and experimentally compares and analyzes the performances of some representative algorithms on the same data. Finally, the existing problems and prospects in this field are presented, which offers some references for researchers engaged in PPI network analyzing.