| 端氨基聚乙二醇-聚乳酸嵌段共聚物的合成及表征 |
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| 引用本文： | 高正炎,郭玲香.端氨基聚乙二醇-聚乳酸嵌段共聚物的合成及表征[J].化工新型材料,2009,37(2). |
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| 作者姓名： | 高正炎 郭玲香 |
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| 作者单位： | 东南大学化学化工学院,南京,211189 |
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| 基金项目： | 江苏省卫生厅重点科研课题 |
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| 摘 要： | 以聚乙二醇为原料,采用四步反应,合成了二碳酸二叔丁酯单保护的氨基聚乙二醇(BOC-PEG-NH2);并以DOe-PEG-NH2为引发剂,引发丙交酯开环聚合,得到了叔丁氧基酰胺基聚乙二醇-聚乳酸嵌段共聚物(BOC-PEG-PLA).在三氟乙酸二氯甲烷溶液中,脱去保护基团,得到了端氨基聚乙二醇-聚乳酸嵌段共聚物(NH2-PEG-PLA).采用核磁共振氢谱(1H-NMR)、紫外光度仪(UV)表征各聚合物的结构,由凝胶色谱仪(GPC)测定嵌段共聚物的分子量以及分子量分布.结果表明:合成的氨基引发在无催化剂条件下能够引发丙交酯开环聚合,制得分子量高、分子量分布窄的双亲性共聚物.通过三氟乙酸脱保护得到了端氨基聚乙二醇-一聚乳酸(NH2-PEG-PLA),且对分子量没有影响.
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| 关 键 词： | 氨基聚乙二醇 端氨基聚乙二醇-聚乳酸 氨基微球 |
Synthesis and characterization of amino terminated poly(ethylene glycol)-poly(lactic acid) block copolymers |
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| Gao Zhengyan,Guo Lingxiang.Synthesis and characterization of amino terminated poly(ethylene glycol)-poly(lactic acid) block copolymers[J].New Chemical Materials,2009,37(2). |
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| Authors: | Gao Zhengyan Guo Lingxiang |
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| Affiliation: | Department of Chemistry and Chemical Engineering;Southeast University;Nanjing 211189 |
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| Abstract: | BOC-PEG-NH2 was synthesized by four-steps.Using BOC-PEG-NH2as initiator,amphiphilic poly(D,L-lactide)-b-poly(ethylene glycol)-BOC block copolymer(PLA-b-PEO-BOC) was synthesized via the ring-opening polymerization of lactide.NH2-PEG-b-PLA was obtained from de-protection of PLA-b-PEO-FOMC.The resultant copolymers structures were characterized by nuclear magnetic resonance and ultraviolet-visible absorption spectrum,and the molecular weight and its distribution of NH2-PEG-PLA were characterized by GPC. |
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| Keywords: | amino PEG amino terminated PEG-b-PLA amino group microsphere |
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