| 一种pH敏感性智能水凝胶的合成与表征 |
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| 引用本文： | 孙姣霞,罗彦凤,彭辉,韩志伟.一种pH敏感性智能水凝胶的合成与表征[J].高分子材料科学与工程,2009(9). |
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| 作者姓名： | 孙姣霞 罗彦凤 彭辉 韩志伟 |
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| 作者单位： | 重庆大学化学化工学院;生物流变科学与技术教育部重点实验室(重庆大学);重庆大学生物工程学院; |
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| 基金项目： | 重庆市自然科学基金资助项目(CSTC2006BB5010) |
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| 摘 要： | 以乙二胺四乙酸酐(EDTAh)和丁二胺(BDA)为原料,通过高温溶液聚合形成含多元环状酰亚胺的共聚物(pEDTAh-BDA-Imide),最后以丁二胺为交联剂,与pEDTAh-BDA-Imide中的酰亚胺发生N-酰化开环反应,生成了侧链含氨基的网络聚合物(BDA-crosslinked-EDTAh-BDA)。该网络聚合物可望成为一种集完全可降解、pH敏感性和生物相容性于一体的新型药物释放水凝胶。采用红外光谱和核磁共振对各共聚物进行了结构表征,采用扫描电镜(SEM)表征了水凝胶的表面形貌。pH敏感性测试表明,BDA-crosslinked-EDTAh-BDA表现出明显的pH响应性。
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| 关 键 词： | 水凝胶 pH敏感 乙二胺四乙酸酐 丁二胺 |
Synthesis and Characterization of a pH-Sensitive Hyhrogel |
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| SUN Jiao-xia,LUO Yan-feng,PENG Hui,HAN Zhi-wei,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing ,China.Synthesis and Characterization of a pH-Sensitive Hyhrogel[J].Polymer Materials Science & Engineering,2009(9). |
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| Authors: | SUN Jiao-xia LUO Yan-feng PENG Hui HAN Zhi-wei Ministry of Education College of Bioengineering Chongqing University Chongqing China |
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| Affiliation: | SUN Jiao-xia1,LUO Yan-feng2,PENG Hui2,HAN Zhi-wei2(1. College of Chemistry & Chemical Engineering,2. Key Laboratory of Biorheological Science and Technology (Chongqing University),Ministry of Education,College of Bioengineering,Chongqing University,Chongqing 400044,China) |
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| Abstract: | A novel pH-sensitive degradable hydrogel based on ethylenediamine tetraacetic dianhydride (EDTAh) was synthesized:firstly,EDTAh reacted with butanediamine (BDA) through thermo-condensation polymerization,producing a copolymer containing cyclic imide groups (pEDTAh-BDA-Imide); then,pEDTAh-BDA-Imide was crosslinked by BDA via N-acylation of the imide groups,yielding the desired network polymer with pendant amino groups (BDA-crosslinked-EDTAh-BDA). BDA-crosslinked-EDTAh-BDA is a promising hydrogel for drug con... |
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| Keywords: | hydrogel pH-sensitive ethylenediaminetetraaceticdianhydride butanediamine |
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