Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine |
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| Affiliation: | 1. i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal;2. INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal;3. FEUP – Faculdade de Engenharia da Universidade do Porto, Departamento de Engenharia Metalúrgica e Materiais, Porto, Portugal;4. FP-ENAS/CEBIMED – University Fernando Pessoa Energy, Environment and Health Research Unit/Biomedical Research Center, Porto, Portugal;5. Laboratory for Bone Metabolism and Regeneration, Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal;6. School of Chemical Engineering, University of Campinas, Campinas, Brazil;7. POLYMAT University of the Basque Country UPV/EHU, Donostia-San Sebastian, Spain;1. Department of Pharmacology, Guangdong Medical College, Dongguan 523808, PR China;2. College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Baoding 071002, PR China;3. Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong |
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| Abstract: | Gold nanoparticles (AuNPs) have arisen a lot of interest in the clinical realms of nanomedicine. Despite the large advances made in cancer research using AuNPs, their use in tissue engineering and regenerative medicine (TERM) is still in its infancy. Herein, it is discussed the properties, functionalization, and emerging use of AuNPs as a multifunctional and multimodal platform for drug delivery, phototherapy, diagnostic and cell imaging purposes. Moreover, the recent reports related to the ability of AuNPs to enhance stem cell differentiation for bone tissue engineering, to enhance the mechanical and adhesive properties of scaffolds and surface topography to guide cell behaviors are addressed. |
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| Keywords: | Gold nanoparticle Tissue engineering Regenerative medicine Scaffold Stem cells |
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