| 骨组织工程用纳米羟基磷灰石/ 壳聚糖多孔支架材料的制备及性能表征 |
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| 引用本文： | 张利,李玉宝,杨爱萍,左奕,吕国玉,魏杰.骨组织工程用纳米羟基磷灰石/ 壳聚糖多孔支架材料的制备及性能表征[J].功能材料,2005,36(2):314-317. |
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| 作者姓名： | 张利 李玉宝 杨爱萍 左奕 吕国玉 魏杰 |
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| 作者单位： | 四川大学,纳米生物材料研究中心,四川大学分析测试中心,四川,成都,610064 |
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| 基金项目： | “863”国际合作重点资助项目(2002AADF3201) |
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| 摘 要： | 以16.7%(质量分数)的柠檬酸水溶液作溶剂,通过粒子沥滤法制备了 n HA/CS多孔材料,并对其进行了IR、XRD、SEM、孔隙率及力学性能测试。结果表明n HA/CS复合材料中羟基磷灰石呈弱结晶状态,复合前后两组分的化学组成未发生显著变化,但两相间发生了相互作用。多孔材料呈高度多孔结构,孔壁上富含微孔,孔间贯通性高;复合材料/致孔剂质量比为1时,多孔材料的孔隙率为 53%,其抗压强度可达17 MPa左右,可以满足组织工程支架材料的要求。
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| 关 键 词： | 羟基磷灰石 壳聚糖 复合材料 柠檬酸 粒子沥滤 多孔支架 |
| 文章编号： | 1001-9731(2005)02-0314-04 |
| 修稿时间： | 2004年4月5日 |
The preparation and characterization of porous scaffold made of nano-hydroxyapatite/chitosan composite for bone tissue engineering |
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| ZHANG Li,LI Yu-bao,YANG Ai-ping,ZUO Yi,LU Guo-yu,WEI Jie.The preparation and characterization of porous scaffold made of nano-hydroxyapatite/chitosan composite for bone tissue engineering[J].Journal of Functional Materials,2005,36(2):314-317. |
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| Authors: | ZHANG Li LI Yu-bao YANG Ai-ping ZUO Yi LU Guo-yu WEI Jie |
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| Abstract: | Porous scaffolds made of nano-hydroxyapatite/chitosan composite were prepared by means of porogen-leaching method and characterized by IR, XRD, SEM. In addition, the porosity and mechanical strength were also tested. The results show that hydroxyapatite in the composite was poorly crystalline, and the chemical compositions of the two phases have not changed before and after being compounded, but interactions between them have occurred. The scaffold shows highly porous structure and the pores are interconnected. The porosity and compressive strength of the scaffold should be desirable for bone tissue engineering. |
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| Keywords: | hydroxyapatite chitosan composite citric acid porogen-leaching porous scaffold |
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