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| PLLA纳米纤维编织缝合线的制备及生物相容性研究 | |
| 引用本文： | 胡雯,黄争鸣,唐亮.PLLA纳米纤维编织缝合线的制备及生物相容性研究[J].功能材料,2009,40(11). |
| 作者姓名： | 胡雯 黄争鸣 唐亮 |
| 作者单位： | 1. 同济大学,材料科学与工程学院,上海,200092 2. 同济大学,航空航天与力学院,上海,200092 3. 同济大学,附属上海肺科医院中心实验室,上海,200433 |
| 摘 要： | 以PLLA为原料,采用静电纺丝和圆盘定向收集得到具有有序排列的纳米纤维束,并将其编织成线,得到PLLA纳米纤维缝合线.对新型可吸收PLLA缝线的微观形貌、血液相容性、细胞毒性进行了性能表征,并测试了其力学性能.结果表明,纳米纤维在一定的圆盘转速下表现出较好的定向性,力学性能良好.缝线在溶血试验中溶血率＜5%,符合医用材料的溶血要求.MTT实验结果表明缝线材料无细胞毒性,且显示出较高的增殖率,说明新型可吸收PLLA纳米纤维缝线具有良好的生物相容性和安全性. |
| 关 键 词： | 聚乳酸 静电纺丝 定向排列 生物相容性 |
Preparation biocompatibility evaluation on plla braided nanofibers suture |
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| HU Wen,HUANG Zheng-ming,TANG Liang.Preparation biocompatibility evaluation on plla braided nanofibers suture[J].Journal of Functional Materials,2009,40(11). | |
| Authors: | HU Wen HUANG Zheng-ming TANG Liang |
| Affiliation: | HU Wen1,HUANG Zheng-ming2,TANG Liang3(1.School of Materials Science and Engineering,Tongji Univesity,Shanghai 200092,China,2.School of Aerospace Engineering and Applied Mechanics,Tongji University,3.Shanghai Pulmonary Hospital,Shanghai 200433,China) |
| Abstract: | PLLA nanofibers was collected by electrospinning and directional collecting disc was used in this experiment,braided suture was fabricated by mini-knitting machine.Micromorphology,blood compatibility,cells toxicity test were characterized of this new type of Absorbable PLLA suture.The results show that nanofibers show better directing property in a certain rotating speed and perform favorable mechnical properties.Hemolysis ratio is less than 5% in hemolysis experiment which reach the standard required.There... |
| Keywords: | PLLA electrospinning orientation arrangement biocompatibility |
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