| 肌肉介导心钠素基因对L-NNA高血压大鼠的作用 |
| |
| 引用本文： | 秦阳君,张晨晖,张继峰,丁金凤,陈光慧,汤健.肌肉介导心钠素基因对L-NNA高血压大鼠的作用[J].高技术通讯,1998,8(2):45-47. |
| |
| 作者姓名： | 秦阳君 张晨晖 张继峰 丁金凤 陈光慧 汤健 |
| |
| 作者单位： | 1. 北京医科大学心血基础研究所,北京,100083
2. 阜外医院心血管研究所,北京,100037 |
| |
| 摘 要： | 用重组人心钠素基因真核表达质粒ｐｃＤＮＡ３／ＡＮＦ，通过基因缝线转移至Ｌ－ＮＮＡ高血压大鼠股四头肌，发现可明显降低Ｌ－ＮＮＡ引起的高血压，并产生明显的利钠利尿作用。提示肌肉介导心钠素基因，作为一种ＤＮＡ药物治疗高血压，可能具有潜在应用价值。
|
| 关 键 词： | 肌肉介导 基因 心钠素 高血压 |
Effect of Intramuscular Transfer of Atrial Natriuretic Factor Eukaryotic Expression Vector on L-NNA Hypertensive Rats |
| |
| Qin Yangjun,Zhang Chenhui,Zhang Jifeng,Chen Kuanghui,Tang Jian.Effect of Intramuscular Transfer of Atrial Natriuretic Factor Eukaryotic Expression Vector on L-NNA Hypertensive Rats[J].High Technology Letters,1998,8(2):45-47. |
| |
| Authors: | Qin Yangjun Zhang Chenhui Zhang Jifeng Chen Kuanghui Tang Jian |
| |
| Abstract: | With the method of gene suture, the ANF cDNA eukaryotic expessing plasmid was transferred into the quadricep of L NNA hypertensive rats. It was found that the blood pressure was significantly decreased, and the ruinary volume and sodium excretion were obviously increased after gene transfer. The results suggest that muscle mediated ANF gene transfer has the potential application in hypertension therapy. |
| |
| Keywords: | Gene drug Atrial Natriaretio faetor Hypertension |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
