Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study |
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| Authors: | Xiaoyi Xu Tongjun Liu Shaohui Liu Kai Zhang Zhen Shen Yuxin Li Xiabin Jing |
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| Affiliation: | (1) National Engineering Laboratory for Druggable Gene and Protein Screening, Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun, 130024, China;(2) Department of General Surgery, First Hospital, Jilin University, Changchun, 130021, China;(3) State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China |
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| Abstract: | The current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (CBD) repair and
reconstruction. Here, poly(l-lactide-co-glycolide) (PLGA, molar ratio LA/GA = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine
the in vitro degradation behavior in bile. The morphology, weight loss, and molecular weight changes were then investigated
in conjunction with evaluations of the mechanical properties of the specimen. Circular tube-shaped PLGA stents with X-ray
opacity were subsequently used in common bile duct exploration (CBDE) and primary suturing in canine models. Next, X-ray images
of CBD stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent
transplantation. The results showed that the PLGA stents exhibited the required biomedical properties and spontaneously disappeared
from CBDs in 4–5 weeks. The degradation period and function match the requirements in repair and reconstruction of CBDs to
support the duct, guide bile drainage, and reduce T-tube-related complications. |
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