Immobilization of gold nanoparticles on solid supports utilizing DNA hybridization |
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Affiliation: | 1. Institut für Anorganische Chemie, RWTH Aachen, Prof.-Pirlet-Str. 1, 52056 Aachen, Germany;2. Biotechnologie und Molekulare Genetik, Universität Bremen, FB2-UZT, Leobener Str., 28359 Bremen, Germany;3. Physikalisches Institut, Universität Münster, Wilhelm-Klemm-Str. 10, 48149 Münster, Germany |
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Abstract: | Self-organization of colloidal metal nanoparticles into micro- and nanostructured assemblies is currently of tremendous interest promising to find new size- and structure-dependent physical properties. Owing to its unique recognition capabilities and physicochemical stability, DNA can be used as a molecular linker for gold nanoparticles and is a promising construction material for their precise spatial positioning. Due to the enormous specificity of nucleic acid hybridization, the site-specific immobilization of DNA-functionalized gold colloids (1–40 nm) to solid supports, previously functionalized with a complementary DNA array, allows the fabrication of novel nanostructured surface architectures. Scanning force microscopy (SFM), used to characterize the intermediate steps of the DNA-directed immobilization (DDI) on a gold substrate, provides initial insight into the specificity and efficiency of this technique. |
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