| 复合磷酸盐多孔生物陶瓷的制备及体外细胞相容性 |
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| 引用本文： | 刘斌,董寅生,林萍华,张俊,苏静. 复合磷酸盐多孔生物陶瓷的制备及体外细胞相容性[J]. 无机材料学报, 2011, 26(7): 759-764. DOI: 10.3724/SP.J.1077.2011.00759 |
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| 作者姓名： | 刘斌 董寅生 林萍华 张俊 苏静 |
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| 作者单位： | (1. 南京信息工程大学 数理学院, 南京 210044; 2. 东南大学 材料科学与工程学院, 南京 211189; 3. 东南大学 医学院, 南京 210009) |
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| 基金项目： | 国家自然科学基金(51002079); 南京信息工程大学科研基金(20080291)~~ |
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| 摘 要： | 以Al2O3-MgO-P2O5磷酸盐为粘结剂, 采用有机泡沫浸渍工艺制备了多孔陶瓷, 采用扫描电镜(SEM)、X射线衍射(XRD)、排水法和压缩实验等表征了多孔陶瓷的孔隙形貌、相组成、孔隙率和力学性能, 并通过体外细胞实验研究了其细胞相容性. 结果表明, Al2O3-MgO-P2O5磷酸盐的加入不仅可以使浆料能够均匀地涂覆在泡沫体上, 也促进了陶瓷的烧结. 得到的多孔陶瓷具有相互连通、分布均匀的孔隙结构(大孔孔径在100~500μm, 还有约为3μm微孔), 平均孔隙率为85.9%±1.6%, 平均压缩强度为(1.04±0.15)MPa; 多孔陶瓷虽然是一种由HA、β-Ca2P2O7和少量含Mg、Al的物相组成的复合磷酸盐陶瓷, 但在体外实验中没有表现出明显的细胞毒性, 并能促进细胞快速增殖与分化, 表明该多孔陶瓷具有良好的细胞亲和性和相容性.
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| 关 键 词： | 复合磷酸盐 多孔陶瓷 Al2O3-MgO-P2O5 细胞相容性 |
| 收稿时间： | 2010-09-15 |
| 修稿时间： | 2010-11-15 |
Preparation of Polyphosphate Porous Bioceramics and in vitro Cytocompatibility |
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| LIU Bin,DONG Yin-Sheng,LIN Ping-Hua,ZHANG Jun,SU Jing. Preparation of Polyphosphate Porous Bioceramics and in vitro Cytocompatibility[J]. Journal of Inorganic Materials, 2011, 26(7): 759-764. DOI: 10.3724/SP.J.1077.2011.00759 |
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| Authors: | LIU Bin DONG Yin-Sheng LIN Ping-Hua ZHANG Jun SU Jing |
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| Affiliation: | (1. College of Math & Physics, Nanjing University of Information & Technology, Nanjing 210044, China; 2. School of Materials Science and Engineering, Southeast University, Nanjing 211189, China; 3. Medical College, Southeast University, Nanjing 210009, China) |
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| Abstract: | The porous ceramics were prepared by the foam impregnation technology using Al2O3-MgO-P2O5 as binder.Porous morphology,crystalline phase,porosity,and mechanical property were investigated by using scaning electron microscope(SEM),X-ray diffraction(XRD),Archimedes drainage method,and compression tests.It was found that Al2O3-MgO-P2O5 phosphate promoted the sintering of ceramics,and improved coating of ceramic slurry over the foams uniformly.The obtained ceramics have connective,uniform pore structures with m... |
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| Keywords: | polyphosphates porous ceramics Al2O3-MgO-P2O5 cytocompatibility |
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