FePS3纳米片制备及其体外光热-光动力学联合治疗性能研究

光学治疗作为一种肿瘤治疗策略具有微创、毒副作用小、治疗效率高等优势而得到广泛研究, 但单一光学治疗并不能完全消除肿瘤。新兴的二维纳米材料在光学治疗领域的优势引起了广泛关注。本研究探索了金属磷三硫族元素化合物FePS₃纳米片的制备及其多功能光学治疗性能。采用高温固相法合成FePS₃块体并通过超声协助的液相剥离法得到FePS₃纳米片, 该纳米片的平均水合粒径小于200 nm (平均153 nm), 对1064 nm激光的光热转换效率为19.7%, 且能在660 nm激光辐照下产生活性氧。细胞实验结果表明, FePS₃纳米片具有良好的光热治疗和光动力学治疗效果。因此, FePS₃纳米片可同时作为光热剂和光敏剂获得光热-光动力学联合治疗肿瘤功能, 肿瘤治疗应用潜力较大。

FePS3 Nanosheets: Preparation and Potential in Photothermal-photodynamic Therapy

Phototherapy, a tumor therapeutic modality, has been widely studied due to its advantages of minimal invasiveness, low side effect, and high therapeutic efficacy. However, single phototherapy cannot achieve complete tumor elimination. Recently, the emerging two-dimensional nanomaterials have attracted great attention in the field of phototherapy. Here, FePS₃ nanosheets were prepared, and then its phototherapeutic properties were investigated. The bulk FePS₃ was synthesized by a high-temperature solid-phase method and FePS₃ nanosheets were obtained by an ultrasonic-assisted liquid phase exfoliating method. The nanosheets displayed particle morphology with average hydrated size of less than 200 nm (153 nm in average), performed photothermal conversion efficiency of 19.7% under 1064 nm laser irradiation, and generated reactive oxygen species under 660 nm laser irradiation. Cell experiment results showed that FePS₃ nanosheets had excellent photothermal and photodynamic therapeutic effects. Therefore, FePS₃ nanosheets can be used as both photothermal agent and photosensitizer to achieve combined photothermal-photodynamic therapy for treating tumors, which shows great application potential.