离子束辅助沉积氧化钛对改善热解碳抗凝血性能作用的初步研究

用离子束辅助沉积的方法在人工心脏瓣膜热解碳材料表面制备氧化钛薄膜，研究其对抗凝血性能的改善情况，以探索新型的人工瓣膜材料．对样本分别进行体外血小板黏附试验和动物体内试验以观察血栓形成的情况．结果表明，相比较传统的热解碳材料而言，氧化钛薄膜处理过的材料上黏附的血小板数目和聚集的血小板团数均明显减少，且血小板伪足数目亦明显减少．动物体内试验亦表明有氧化钛薄膜的样本表面形成的血栓较传统的热解碳材料要少，且没有热解碳材料表面有大量的血小板聚集和纤维蛋白形成．研究结果显示用离子束辅助沉积技术制备的氧化钛薄膜，其抗凝血性能优于目前临床应用的热解碳材料，很可能成为新一代的人工瓣膜材料。

TiO2 Thin Film Deposited by Enhanced Ion Beam Technique to Improve Anti-coagulability of Pyrolysis Carbon Applied to Artificial Heart Valves

A new kind of materials applied to the artificial heart valve, rutile-TiO2 thin film on low temperature isotropic pyrolysis carbon (LTI-carbon) was deposited through the enhanced ion beam approach. The thrombosis on the surface of samples was observed through platelet adhesion in vitro and animal experiments in vivo, respectively. Compared with LTI-carbon material, there is much less platelets adhesion, aggretated and coagulated as well as deformed on the surface of the thin film. Animal experiments in vivo also show that the amount of thrombus on the observed surface is much less than that of LTI-carbon. There are numerous platelets and fibrin aggregated and formed on the surface of LTI-carbon, but not on the surface of the thin film. The anti-coagulability of the deposited rutile-Ti02 thin film is much better than that of LTI-carbon traditionally used in artificial heart valves. And it also indicates that the deposited TiO2 thin film is a new kind of promising materials applied to artificial heart valves.