Intermittent and short daily hemodialysis increase HGF plasma levels and diminish HCV viral load |
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| Authors: | Barril G Bartolome J Sanz P Buoncristiani E Traver JA Selgas R Carreno V Buoncristiani U |
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| Affiliation: | Nephrology, HU Princesa, Madrid, Spain;;Fundacion E.Hepatitis Virales, Madrid, Spain and;Nephrology, H S.Silvestrini, Perugia, Italy. |
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| Abstract: | Decrease of HCV viral load and HGF plasma levels increase have been related to HD sessions. Beneficial effects of HGF stimulation in HD on the outcome of HCV liver disease have been described. Aim was to analyze potential differences between intermittent (3 × week) and short daily (6 × week) HD, examining differences between HCV+ and – pts. We studied 41 pts from 2 HD centres, 26 on intermittent HD (6 on line HF), 8 HCV+, and 15 on short‐daily HD with 4 HCV+ 40 pts used synthetic HD membranes (low‐flux and high‐flux). Among HCV + we determined viral load by Amplicor (Roche) pre- and post- HD. All pts were studied for HGF levels (ELISA) baseline, 15 min, end, and at start of the following session viral load is significantly higher preHD and decreases over session. High‐flux membranes were more efficient in reducing viremia (67% vs 45%), which level was higher pre‐ and post‐HD principally in patients using low‐flux membranes. Viremia in DHD is lower than in intermittent (470067.3 ± 663974.5 vs 1015695.5 ± 1202679.0). |
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