Magnetic Metal–Organic Frameworks: γ‐Fe2O3@MOFs via Confined In Situ Pyrolysis Method for Drug Delivery |
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| Authors: | Yi‐nan Wu Meimei Zhou Shu Li Zehua Li Jie Li Baozhen Wu Guangtao Li Fengting Li Xiaohong Guan |
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| Affiliation: | 1. College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, , Shanghai, 200092 P. R. China;2. Key Lab of Organic Optoelectronic and Molecular Engineering, Department of Chemistry, Tsinghua University, , Beijing, 100084 P. R. China |
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| Abstract: | A general one‐step in situ pyrolysis route for the construction of metal–organic frameworks encapsulating superparamagnetic γ‐Fe2O3 NPs dispersed in the confined cavities of MOFs homogeneously is described. The integration of γ‐Fe2O3 NPs or clusters into MOFs can endow these porous materials with superparamagnetic element. By the combination of the thermal stability of MOFs and pyrolysis of metal triacetylacetonate complex at matched conditions, the porous structure of MOFs are well maintained while the size‐induced superparamagnetic property of nano γ‐Fe2O3 is obtained. As a proof of concept, both the γ‐ Fe2O3@ZIF‐8 and γ‐Fe2O3@MIL‐53(Al) were successfully prepared, and the latter was chosen to demonstrate its potential drug delivery as a magnetic MOF. |
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| Keywords: | metal– organic frameworks superparamagnetism maghemite nanoconfinement drug delivery |
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