| 复频聚焦超声激活血卟啉杀伤肿瘤细胞K562的实验研究 |
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| 引用本文： | 石新军,朱旭宁,尚志远.复频聚焦超声激活血卟啉杀伤肿瘤细胞K562的实验研究[J].声学技术,2004,23(2):84-87. |
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| 作者姓名： | 石新军 朱旭宁 尚志远 |
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| 作者单位： | 1. 武警广州指挥学院,广州,510440
2. 陕西师范大学应用声学研究所,西安,710062 |
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| 摘 要： | 为了研究单复频超声激活血卟啉对人体肿瘤细胞的杀伤效应，利用自制的复频聚焦换能器激活血卟啉，以肿瘤细胞K562：为研究对象，采用MTF法(四唑盐比色法)检测在不同超声处理时间、不同频率、不同溶液环境下、不同孵育时间条件下，声动力学激活血卟啉法对肿瘤细胞的杀伤效应。结果表明，复频聚焦超声激活血卟啉对肿瘤细胞具有较强的杀伤效应，是一种有应用前景的治疗肿瘤的新技术。
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| 关 键 词： | 复频聚焦超声激活 抗肿瘤效应 血卟啉 声动力学疗法 肿瘤细胞 |
| 文章编号： | 1000-3630(2004)02-0084-04 |
| 收稿时间： | 2003/7/14 0:00:00 |
| 修稿时间： | 2003/10/24 0:00:00 |
Cell killing of K562 cells by hematoporphyrin derivatives activated by focused bi-frequency ultrasound |
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| SHI Xin-jun,ZHU Xu-ning and SHANG Zhi-yuan.Cell killing of K562 cells by hematoporphyrin derivatives activated by focused bi-frequency ultrasound[J].Technical Acoustics,2004,23(2):84-87. |
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| Authors: | SHI Xin-jun ZHU Xu-ning and SHANG Zhi-yuan |
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| Abstract: | A bi-frequency focusing ultrasonic transducer is used to activate hematoporphyrin in order to kill cancer cells of K(562). The cell-killing effects of the sonodynamic-therapy with different time, frequencies, liquor conditions and incubation time are studied. It is concluded that bi-frequency focused ultrasound can increase the cell-killing effect in homodynamic therapy. The longer the irradiation time, the better the cell-killing effect. |
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| Keywords: | cell-killing effect bi-frequency focused ultrasound hematoporphyrin onodynamic-therapy |
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