| 超声辅助合成多孔pH敏感性海藻酸钠水凝胶及其控释行为 |
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| 引用本文： | 吴称意,李聪,张旭,程超,吴少尉,周倩,覃姗姗.超声辅助合成多孔pH敏感性海藻酸钠水凝胶及其控释行为[J].材料导报,2018,32(7):1187-1191, 1196. |
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| 作者姓名： | 吴称意 李聪 张旭 程超 吴少尉 周倩 覃姗姗 |
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| 作者单位： | 湖北民族学院化学与环境工程学院,恩施445000;湖北省生物资源保护与利用重点实验室,恩施445000
湖北民族学院化学与环境工程学院,恩施,445000 |
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| 基金项目： | 湖北省教育厅科学研究计划资助项目 |
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| 摘 要： | 利用超声波辅助接枝聚合制备多孔NaAlg-g-P(NVP-co-NHMAA)水凝胶,利用傅里叶红外光谱(FT-IR)、热重分析(TGA)和扫描电镜(SEM)对NaAlg-g-P(NVP-co-NHMAA)的结构和形态进行了表征,同时还研究了NaAlg-g-P(NVP-coNHMAA)的溶胀行为和pH敏感性。以5-氟尿嘧啶(5-FU)作为模型药物,研究了NaAlg-g-P(NVP-co-NHMAA)水凝胶在模拟胃液(SGF,pH=1.2)和模拟肠液(SIF,pH=7.4)下的控制释放行为,结果显示,在pH=7.4时,11h内该水凝胶的累积释放率高达80.2%,而在pH=1.2时只有50.2%,这表明NaAlg-g-P(NVP-co-NHMAA)水凝胶可以作为结肠靶向药物输送载体。
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| 关 键 词： | 水凝胶 膨胀 持续释放 5-氟尿嘧啶 pH 敏感性 海藻酸钠 hydrogel swelling sustained release 5-fluorouracil pH-sensitivity sodium alginate |
Ultrasound-assisted Synthesis of pH-sensitive Macroporous SodiumAlginate-based Hydrogels and Sustained Release |
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| WU Chengyi,LI Cong,ZHANG Xu,CHENG Chao,WU Shaowei,ZHOU Qian and QIN Shanshan.Ultrasound-assisted Synthesis of pH-sensitive Macroporous SodiumAlginate-based Hydrogels and Sustained Release[J].Materials Review,2018,32(7):1187-1191, 1196. |
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| Authors: | WU Chengyi LI Cong ZHANG Xu CHENG Chao WU Shaowei ZHOU Qian and QIN Shanshan |
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| Affiliation: | Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000;Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Enshi 445000,Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000,Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000,Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000,Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000,Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000 and Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000 |
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| Abstract: | A novel macroporous NaAlg-g-poly(NVP-co-NHMAA)was synthesized by a free radical grafting polymerization with ultrasound radiation,the structure and morphologies of NaAlg-g-poly(NVP-co-NHMAA)were characterized by Fourier trans-form infrared spectroscope (FT-IR),thermogravimetric analysis (TGA)and scanning electron microscopy(SEM).The swelling be-havior and pH sensitivity of NaAlg-g-poly(NVP-co-NHMAA)were investigated.5-Fluorouracil (5-FU)was used as model drug to study the release behavior in simulated gastric fluids (SGF,pH=1.2)and simulated intestinal fluids (SIF,pH=7.4).The results displayed that the cumulative release ratio was up to 80.2% in pH=7.4 for 11 h,only 50.2% in pH=1.2.It means that this hydrogel was suitable for colon-specific drug delivery systems. |
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| Keywords: | hydrogel swelling sustained release 5-fluorouracil pH-sensitivity sodium alginate |
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