| 新型胶原/聚丙烯酸互穿网络pH敏感水凝胶的制备及性能研究 |
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| 引用本文： | 李凤娟,林炜,程庆甦,穆畅道.新型胶原/聚丙烯酸互穿网络pH敏感水凝胶的制备及性能研究[J].材料导报,2009,23(4). |
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| 作者姓名： | 李凤娟 林炜 程庆甦 穆畅道 |
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| 作者单位： | 1. 四川大学化学工程学院制药与生物工程系,成都,610065
2. 四川大学皮革化学与工程教育部重点实验室,成都,610065 |
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| 基金项目： | 国家自然科学基金，教育部新世纪优秀人才支持计划 |
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| 摘 要： | 以Bis为交联剂,采用互穿网络(IPN)技术制备胶原/聚丙烯酸pH敏感水凝胶.研究了不同配比的水凝胶的溶胀动力学、pH敏感性及pH溶胀-退胀特性,并利用傅里叶变换红外光谱法(FTIR)和差示量热扫描法(DSC)对其结构进行表征.结果显示:制备的水凝胶具有较快的溶胀速率,在13min时吸水率可达93%左右;水凝胶有明显的pH敏感性且pH溶胀-退胀可逆性良好.FTIR和DSC结果表明,在保持胶原三股螺旋结构的同时,材料间形成了互穿网络,材料的热稳定性显著提高,从而扩大了材料的应用范围.
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| 关 键 词： | 胶原 聚丙烯酸 互穿网络 水凝胶 pH敏感 |
Synthesis and Characterization of pH Sensitive Collagen/Poly (Acrylic Acid) IPN Hydrogels |
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| LI Fengjuan,LIN Wei,CHENG Qingsu,MU Changdao.Synthesis and Characterization of pH Sensitive Collagen/Poly (Acrylic Acid) IPN Hydrogels[J].Materials Review,2009,23(4). |
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| Authors: | LI Fengjuan LIN Wei CHENG Qingsu MU Changdao |
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| Affiliation: | 1 Department of Pharmaceutical and Biological Engineering;School of Chemical Engineering;Sichuan University;Chengdu 610065;2 The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education;Chengdu 610065 |
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| Abstract: | A new system of pH-sensitive hydrogels composed of collagen and polyacrylic acid(AAc)is prepared by using the interpenetrating polymer network(IPN)in the presence of Bis as crosslinking agent.The hydrogels synthesized display a good swelling behavior in water,and its absorbency can get up to about 93% in 13 minutes.The property measurements of the hydrogels show that they exhibit an obvious pH sensitivity and are stable after the repeated pH swelling experiments.The molecular structure of the hydrogel is st... |
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| Keywords: | collagen PAAc IPN hydrogel pH-sensitive |
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