| 氨基酸改性聚乳酸共聚物的合成及降解研究进展 |
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| 引用本文： | 樊国栋,白晓丹.氨基酸改性聚乳酸共聚物的合成及降解研究进展[J].材料导报,2011,25(21):95-99. |
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| 作者姓名： | 樊国栋 白晓丹 |
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| 作者单位： | 陕西科技大学化学与化工学院,教育部轻化工助剂化学与技术重点实验室,西安710021 |
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| 基金项目： | 陕西省科技攻关项目(2008K07-32);陕西科技大学研究生创新基金 |
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| 摘 要： | 为了改善聚乳酸的降解速率,提高其与细胞的亲和性,氨基酸对聚乳酸的改性研究引起了人们的关注。综述了聚(乳酸-氨基酸)共聚物的各种合成路线及产物降解性能的研究进展。在聚乳酸(PLA)分子中引入氨基酸,可以使产物的大分子侧链获得氨基、羟基、羧基等活性基团。与PLA相比,此类聚合物的降解性能有所提高,具有两亲性和良好的细胞相容性,可用于药物缓释体系及组织工程。
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| 关 键 词： | 聚乳酸 氨基酸 共聚物 改性 降解性 |
Advances in Synthesis and Degradation of Amino Acid Modified Poly (Lactic Acid) Copolymers |
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| FAN Guodong,BAI Xiaodan.Advances in Synthesis and Degradation of Amino Acid Modified Poly (Lactic Acid) Copolymers[J].Materials Review,2011,25(21):95-99. |
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| Authors: | FAN Guodong BAI Xiaodan |
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| Affiliation: | (Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi’an 710021) |
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| Abstract: | In order to improve the degradation rate and cellular affinity of poly(lactic acid)(PLA),more attentions are attracted to the modification of PLA by amino acids.The various of synthetic routes and degradation of poly(lactic acid-co-amino acid) copolymers are introduced.Poly(lactic acid-co-amino acid)s have reactive side-chain groups of-NH2,-OH,-COOH groups corresponding to amino acids.Compared with poly(lactic acid)(PLA),the degradation of poly(lactic acid-co-amino acid) increases,which has amphiphilic structure and cellular affinity,can be used for drug delivery systems and tissue engineering. |
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| Keywords: | poly(lactic acid) amino acids copolymer modification degradation |
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