火焰干燥法制备低结晶度羟基磷灰石微球(英文)

利用火焰干燥法将3种不同性质的羟基磷灰石(HA)料浆分别制得不同结构的微球。通过透射电镜(TEM)、X线衍射仪(XRD)和扫描电镜(SEM)分别研究不同磷灰石料浆中颗粒的微观结构、所得HA微球的相组成及其表面形貌,进而分析料浆性质及干燥工艺参数对所得HA微球结构的影响。TEM结果表明,随着磷灰石料浆反应陈化时间的延长,其中的纳米颗粒形貌由球状的非晶态转变为针状的纳米晶态;低温条件下HA料浆的结晶程度明显降低。XRD结果表明:火焰干燥所得3种HA微球的结晶程度和其对应料浆的结晶程度一致。SEM结果显示:去氨水后的纯HA料浆经火焰干燥所得微球的球形度最好,含有氨水的HA料浆所得微球具有表面开口的空心结构,而冰水混合物料浆所得HA微球球形度最差。

Fabrication of hydroxyapatite microspheres with poor crystallinity using a novel flame-drying method

Three kinds of hydroxyapatite (HA) microspheres were prepared using a flame-drying method. The morphologies and selected area diffraction of HA slurries were determined by TEM. The phase composition, and morphologies were studied by TEM, X-ray diffractometer (XRD), scanning electron microscope (microstructure, SEM), respectively. The TEM result shows that the slurries are composed of nano-particle HA. With the aging time of HA slurry prolonging, the morphology of HA particle changes from spherical ACP (amorphous calcium phosphate) to rod-like acicular nano-crystal morphology. Low temperature can also cause the crystallinity degree of HA slurry decrease obviously. The XRD result shows that the crystallinity of HA microspheres prepared from three kinds of HA slurry is consistent with its corresponding slurry. The SEM result shows that the sphericity of the microspheres prepared by pure HA slurry without ammonia water is the best among three kinds of microspheres, then the HA slurry containing ammonia solution forms the hollow microspheres with open pore, and ice-water mixture flurry.