| 十六烷基三甲基溴化铵修饰的羧基化单壁碳纳米管的细胞毒性 |
| |
| 引用本文： | 甘丽,阎雪彬,杨金凤,谷永红,黄东,章饶香,黄利华.十六烷基三甲基溴化铵修饰的羧基化单壁碳纳米管的细胞毒性[J].中国有色金属学会会刊,2013,23(11):3346-3352. |
| |
| 作者姓名： | 甘丽 阎雪彬 杨金凤 谷永红 黄东 章饶香 黄利华 |
| |
| 作者单位： | [1]中南大学湘雅三医院,长沙410013 [2]中南大学粉末冶金国家重点实验室,长沙410083 [3]中南大学湘雅医学院附属肿瘤医院,长沙410013 [4]中南大学疼痛医学研究所,长沙410013 |
| |
| 基金项目： | Project （81172546） supported by the National Natural Science Foundation of China; Project （20120162110078） supported by Doctoral Fund of Ministry of Education of China; Project （2011 ssxp198） supported by the Graduate Degree Thesis Innovation Foundation of Central South University, China; Project （13JJ2015） supported by Hunan Provincial Natural Science Foundation of China |
| |
| 摘 要： | 采用十六烷基三甲基溴化铵（CTAB）作为表面活性剂修饰羧基化的单壁碳纳米管（SWNT-COOH/CTAB），并对原始单壁碳纳米管（SWNTs）与羧基化修饰的单壁碳纳米管（SWNT-COOH）进行材料学特征比较。通过细胞活力和细胞凋亡实验对SWNTs、SWNT-COOH和SWNT-COOH/CTAB的细胞毒性进行比较。结果表明，羧基化修饰的单壁碳纳米管比原始单壁碳纳米管的毒性小，单壁碳纳米管经羧基化后其毒性降低；浓度及时间曲线显示SWNT-COOH/CTAB的毒性与表面活性剂CTAB相关，CTAB和 SWNT-COOH/CTAB的细胞毒性在低浓度范围内（0.5-25μg/mL）是可接受的。十六烷基三甲基溴化铵修饰的羧基化单壁碳纳米管在低浓度范围（0.5-25μg/mL）内可以较安全地用于生物医学领域。
|
| 关 键 词： | 碳纳米管 十六烷基三甲基溴化铵 毒性 酸化 凋亡 |
| 收稿时间： | 19 November 2012 |
Cytotoxicity effect assessment of acid purified carbon nanotubes modified with cetyltrimethyl ammonium bromide |
| |
| Li GAN,Xue-bin YAN,Jin-feng YANG,Yong-hong GU,Dong HUANG,Rao-xiang ZHANG,Li-hua HUANG.Cytotoxicity effect assessment of acid purified carbon nanotubes modified with cetyltrimethyl ammonium bromide[J].Transactions of Nonferrous Metals Society of China,2013,23(11):3346-3352. |
| |
| Authors: | Li GAN Xue-bin YAN Jin-feng YANG Yong-hong GU Dong HUANG Rao-xiang ZHANG Li-hua HUANG |
| |
| Affiliation: | 1. The Third Xiangya Hospital, Central South University, Changsha 410013, China; 2. State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China; 3. The Affiliated Tumor Hospital of Xiangya Medical School of Central South University, Changsha 410013, China; 4. Institute of Pain Medicine, Central South University, Changsha 410013, China |
| |
| Abstract: | The cytotoxicities of single-walled carbon nanotubes （SWNTs） and acid purified single-walled carbon nanotubes （SWNT-COOH） were investigated by spectroscopic analysis. Cell viability and cell apoptosis were applied to assessing the cytotoxicity of SWNT-COOH, cetyltrimethyl ammonium bromide （CTAB） and acid purified carbon nanotubes modified with cetyltrimethyl ammonium bromide （SWNT-COOH/CTAB）. The results indicate that SWNTs are more toxic than SWNT-COOH. Concentration and time-curve analyses indicate that cytotoxicity of SWNT-COOH/CTAB is more related to the toxicity of the surfactant CTAB. The cytotoxicity effect of CTAB and SWNT-COOH/CTAB is acceptable at low concentrations （0.5-25μg/mL）. The cytotoxicity observation suggests that SWNT-COOH/CTAB can safely applied to biomedical field at low concentrations （0.5-25μg/mL）. |
| |
| Keywords: | single-walled carbon nanotube cetyltrimethyl ammonium bromide cytotoxicity acid purification apoptosis |
| 本文献已被 维普 ScienceDirect 等数据库收录！ |
