| 顺式-水杨酸-(反式-(-)-1,2-环己二胺)合铂(II)的合成、表征及抗肿瘤活性 |
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| 引用本文： | 朱泽兵,金 全,徐红花,普绍平,王庆琨,李学杰,温志寿,王 蒙.顺式-水杨酸-(反式-(-)-1,2-环己二胺)合铂(II)的合成、表征及抗肿瘤活性[J].贵金属,2014,35(1):56-58,62. |
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| 作者姓名： | 朱泽兵 金 全 徐红花 普绍平 王庆琨 李学杰 温志寿 王 蒙 |
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| 作者单位： | 昆明贵研药业有限公司云南省铂族金属抗肿瘤药物工程技术研究中心;云南省药物研究所; |
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| 基金项目： | 云南省重点科技计划项目(2010DH021) |
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| 摘 要： | 用顺式-二碘-(反式-(-)-1,2-环己二胺)合铂(Ⅱ)先后与硝酸银和水杨酸反应,制备得到新的铂配合物顺式-水杨酸-(反式-(-)-1,2-环己二胺)合铂(Ⅱ)。采用元素分析、质谱、核磁共振氢谱和红外光谱等方法分析了其组成和结构,采用SRB比色法对配合物进行了初步体外活性评价。结果显示合成的化合物结构与理论一致,化合物对肺癌细胞株(A549)和口腔表皮样癌细胞株(KB)的IC50值分别为2.3和3.1μg/mL。
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| 关 键 词： | 有机化合物 铂配合物 水杨酸 合成 抗癌活性 |
| 收稿时间： | 2013/10/28 0:00:00 |
Synthesis, Characterization and Antitumor Activities of Cis-salicylicacid- [trans-(-)-1,2-cyclohexanediamine] Platinum(II) |
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| ZHU Zebing,JIN Quan,XU Honghu,PU Shaoping,WANG Qingkun,LI Xuejie,WEN Zhishou and WANG Meng.Synthesis, Characterization and Antitumor Activities of Cis-salicylicacid- [trans-(-)-1,2-cyclohexanediamine] Platinum(II)[J].Precious Metals,2014,35(1):56-58,62. |
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| Authors: | ZHU Zebing JIN Quan XU Honghu PU Shaoping WANG Qingkun LI Xuejie WEN Zhishou and WANG Meng |
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| Affiliation: | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Institute of Materia Medica, Kunming 650111, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China |
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| Abstract: | |
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| Keywords: | organic compound platinum complex salicylic acid synthesis antitumor activity |
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