| 顺铂注射液的高效液相色谱分析 |
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| 引用本文： | 刘祝东,刘洋,杨一昆,熊惠周,高文桂,余尧. 顺铂注射液的高效液相色谱分析[J]. 贵金属, 2001, 22(2): 32-35 |
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| 作者姓名： | 刘祝东 刘洋 杨一昆 熊惠周 高文桂 余尧 |
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| 作者单位： | 昆明贵金属研究所, |
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| 摘 要： | 提出了测定顺铂注射液中顺铂含量的反相高效液相色谱法，其线性相关系数为0．994，精确度为0．45％（n＝8），顺铂的回收率为99．7％。该法也能用于顺铂注射液中杂质反铂的测定，实现顺铂与水合物、三氯氨铂（铂B）的分离。提出了用氯化钠溶液替代空白溶剂（顺铂注射液所用的溶剂简称）作为顺铂对照品溶剂的可能性。
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| 关 键 词： | 顺铂注射液 高效液相色谱分析 抗癌药物 |
| 文章编号： | 1004-0676(2001)02-0032-04 |
| 修稿时间： | 1999-05-15 |
Analysis of Cisplatin Injection by High Performance Liquid Chromatography |
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| Liu Zhudong,Liu Yang,Yang Yikun,Xiong Huizhou,Gao Wengui,Yu Yao. Analysis of Cisplatin Injection by High Performance Liquid Chromatography[J]. Precious Metals, 2001, 22(2): 32-35 |
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| Authors: | Liu Zhudong Liu Yang Yang Yikun Xiong Huizhou Gao Wengui Yu Yao |
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| Abstract: | A method of determining content of cisplatin in cisplatin injection has been studied by reversed-phase high performance liquid chromatography having linear relative coefficient 0 994 with the accuracy of 0 45%(n=8).The recovery rate of cisplatin was 99 7%.the transplatin in cisplatin injection could also be determined by the present method.The experimental results showed the possibility of blank solvent for making cisplatin injection replace by sodium chloride solution as contrast solvent. |
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| Keywords: | Cisplatin injection High performance liquid chromatograph Analysis |
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