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| 3-氯-1, 1-环丁烷二羧酸根·二氨合铂(Ⅱ)的合成及抗肿瘤活性研究 | |
| 引用本文： | 高传柱,普绍平,刘伟平,高文桂.3-氯-1, 1-环丁烷二羧酸根·二氨合铂(Ⅱ)的合成及抗肿瘤活性研究[J].贵金属,2007,28(2):37-39. |
| 作者姓名： | 高传柱 普绍平 刘伟平 高文桂 |
| 作者单位： | 1. 昆明贵金属研究所,云南,昆明,650221;昆明贵研药业有限公司,云南,昆明,650221 2. 昆明贵研药业有限公司,云南,昆明,650221;昆明理工大学,云南,昆明,650093 3. 昆明贵金属研究所,云南,昆明,650221 |
| 摘 要： | 根据目前临床使用的铂类抗癌药物的缺点和不足,作者报道了一种结构新颖的铂类配合物的合成方法,通过元素分析、质谱、红外和核磁共振氢谱等对合成物进行了结构表征,确认合成物为目标化合物.采用SRB比色法,测定该化合物对A549细胞及KB细胞的半数抑制浓度(IC50)分别为4.8mg/L和18.0mg/L. |
| 关 键 词： | 药物化学 铂类配合物 合成 结构表征 体外抗肿瘤活性试验 |
| 文章编号： | 1004-0676(2007)02-0037-03 |
| 修稿时间： | 2006-05-15 |
Synthesis and Anticancer Activity of 3-chloro-1,1-dicarboxycyclobutane Diammine Platinum(Ⅱ) |
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| GAO Chuanzhu,PU Shaoping,LIU Weiping,GAO Wengui.Synthesis and Anticancer Activity of 3-chloro-1,1-dicarboxycyclobutane Diammine Platinum(Ⅱ)[J].Precious Metals,2007,28(2):37-39. | |
| Authors: | GAO Chuanzhu PU Shaoping LIU Weiping GAO Wengui |
| Affiliation: | 1. Kunming Institute of Precious Metals, Kunming, Yunnan 650221, China; 2. Kunming Guiyan Pharmaceutical Co.Ltd., Kunming,Yunnan 650221, China; 3. Kunming Science and Engineering University, Kunming, Yunnan 650093, China |
| Abstract: | Platinum-based drugs are one of the most important anticancer drugs in clinical use.In this paper,a new platinum-based complex,3-chloro-1,1-dicarboxycyclobutane diammine platinum(II) was synthesized and its structures was characterized by element analysis,MS,IR,and 1H-NMR.The synthesized complex is confirmed to be the target compound.The IC50 of the compound is 4.8mg/L for A549 cell and 18.0 mg/L for KB cell respectively. |
| Keywords: | pharmaceutical chemistry platinum-based complex synthesize structure characterization IC50 |
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