| 铂类抗肿瘤药物甲啶铂的水合反应研究 |
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| 引用本文： | 陈宏,栾春芳,丛艳伟,张 琪,普绍平.铂类抗肿瘤药物甲啶铂的水合反应研究[J].贵金属,2014,35(3):10-13. |
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| 作者姓名： | 陈宏 栾春芳 丛艳伟 张 琪 普绍平 |
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| 作者单位： | 昆明贵金属研究所稀贵金属综合利用新技术国家重点实验室;昆明贵研药业有限公司云南省铂族金属抗肿瘤药物工程技术研究中心; |
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| 基金项目： | 云南省科技厅重点新产品开发计划“抗肿瘤化学I类新药甲啶铂注射液的临床前预研究”(2013BC010) |
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| 摘 要： | 采用高效液相色谱研究了抗肿瘤药物甲啶铂的水合反应,以及甲啶铂在0.9%NaCl溶液中的稳定性。结果表明,甲啶铂的水合反应遵循一级反应动力学规律,20℃时反应速率常数为k=0.03086h-1,半衰期22.5 h,反应活化能E=80.6 kJ/mol;在0.9%NaCl溶液中,甲啶铂的水合反应被抑制,反应达到平衡后,甲啶铂的降解不超过4%。
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| 关 键 词： | 药物化学 抗肿瘤药物 甲啶铂 水合反应 一级反应 |
| 收稿时间： | 2014/2/21 0:00:00 |
The Study of Aquation of Picoplatin, a Platinum-based Anti-tumor Drug |
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| CHEN Hong,LUAN Chunfang,CONG Yanwei,ZHANG Qi and PU Shaoping.The Study of Aquation of Picoplatin, a Platinum-based Anti-tumor Drug[J].Precious Metals,2014,35(3):10-13. |
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| Authors: | CHEN Hong LUAN Chunfang CONG Yanwei ZHANG Qi and PU Shaoping |
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| Affiliation: | State Key Laboratory Advanced Technologies of Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals, Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China;Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China |
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| Abstract: | HPLC analytical method was used to investigate the aquation of picoplatin, and the stability of picoplatin in 0.9% NaCl solution. The results show that the aquation of picoplatin followed the law of the first-order reaction, the rate constant was 0.03086 h-1, the half life period was 22.5 h, the activation energy was 80.6 kJ/mol. Picoplatin is stable in 0.9% NaCl solution, the degradation did not exceed 4% when the reaction achieved balance. |
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| Keywords: | medicinal chemistry platinum-based anti-tumor drug picoplatin aquation the first-order reaction |
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