医用材料聚醚醚酮等离子喷涂表面改性研究进展

聚醚醚酮材料(PEEK)具有良好的生物相容性、化学稳定性、X射线可穿透性及优异的力学性能，广泛用于创伤、脊柱和关节等生物医疗领域。然而，PEEK属于生物惰性材料，其骨整合性不足，这在一定程度上限制了该材料在骨修复与替换等领域的发展和应用。等离子喷涂技术由于工艺简单、经济，喷涂涂层的黏结强度高等特点，是解决聚醚醚酮材料骨整合能力不足的重要表面涂层改性技术。首先，简述了等离子喷涂工艺的涂层沉积机理，并分别对等离子喷涂钛以及羟基磷灰石两种常用涂层进行了介绍;其次，从不同喷涂工艺以及喷涂参数对涂层的影响出发，详细介绍了近几年对PEEK基等离子喷涂涂层的结合强度等机械性能的最新研究进展，并对等离子喷涂过程对PEEK基体的机械强度、疲劳强度、热性能和化学降解等初始性能影响进行了总结与评价，详细介绍了PEEK基等离子喷涂涂层体内外生物性能的最新研究进展;最后，展望了等离子喷涂改性PEEK基材料的临床应用前景，以期为未来设计新型PEEK基生物材料提供理论指导。

Research Advance in Medical Material Polyether-ether-ketone of Surface Modification by Plasma Spraying

Polyether ether ketone (PEEK) has the advantages of high mechanical strength, excellent chemical stability, and transparency to diagnostic X-rays, and its density and elasticity is closer to bones compared to metals. PEEK is widely used in biomedical fields such as trauma, spine, and joints. However, PEEK is a bioinert material with insufficient osteointegration, which limits the development and application in bone repair and replacement to a certain extent. Plasma spraying (PS) technology is an important surface coating modification technology to solve the problem of bone integration of PEEK materials due to its simple process, economy, and high adhesive strength of the coatings. Firstly, this paper briefly describes the coating deposition mechanism of PS process, then titanium (Ti) and hydroxyapatite (HA) coatings manufactured by PS are introduced respectively; Secondly, based on the different spraying processes and spraying parameters, the latest research progress of plasma sprayed PEEK-based coatings on mechanical properties such as bonding strength in recent years is introduced in detail. The effects of PS process on the initial properties of PEEK substrate, such as mechanical strength, fatigue strength, thermal properties and chemical degradation are summarized and evaluated; The latest research progress of plasma sprayed PEEK-based coatings on biological properties in vitro and in vivo is also introduced in detail; Finally, the clinical application of plasma sprayed PEEK is prospected to provide theoretical guidance for the design of new PEEK-based biomaterials in the future.